What do systematic reviews say?

9 questions · 12 findings · 2 reviews · related questions CL0289

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No studies found 0 · 0%GRADE not reported 10 · 83.3%Very low 0 · 0%Low 2 · 16.7%Moderate 0 · 0%High 0 · 0%

Platelet-rich fibrin (PRF) graft vs Mineral trioxide aggregate (MTA)

Overall success (composite of clinical and radiographic success) · Patients with carious pulp exposure in immature permanent teeth undergoing pulpotomy

The two trials of PRF versus MTA for success gave contradictory results and were not pooled (ungraded).

1 finding from 1 review

Comparative efficacy of materials used in patients undergoing pulpotomy or direct pulp capping in carious teeth: A… 2023 All outcomes
≥6 months follow-up · Dental/endodontic clinical settings across multiple countries (university, hospital, specialist and general dental practice); permanent teeth with carious pulp exposure
PRF vs MTA was investigated in 2 RCTs (Alawwad 2020; Keswani 2014) for the primary outcome; the two trials provided contradictory evidence and differed in risk of bias, so were not pooled. Weak evidence.
2 studies
GRADE not reported

Biodentine vs Mineral trioxide aggregate (MTA)

Overall success (composite of clinical and radiographic success) · Patients with carious pulp exposure in permanent teeth undergoing DPC or pulpotomy

MTA and Biodentine performed comparably for clinical and radiographic success (5 RCTs, not pooled; ungraded).

1 finding from 1 review

Comparative efficacy of materials used in patients undergoing pulpotomy or direct pulp capping in carious teeth: A… 2023 All outcomes
≥6 months follow-up · Dental/endodontic clinical settings across multiple countries (university, hospital, specialist and general dental practice); permanent teeth with carious pulp exposure
Biodentine vs MTA was the second most frequent comparison (5 RCTs) for the primary outcome but was not pooled owing to substantial clinical/statistical heterogeneity; the panel of per-trial forest plots (Figure 8)…
5 studies
GRADE not reported

Biodentine vs Calcium hydroxide (CH)

Overall success (composite of clinical and radiographic success) · Permanent teeth with carious pulp exposure

Biodentine may increase pulpotomy success versus calcium hydroxide at marginal significance (ungraded).

1 finding from 1 review

Efficacy of pulpotomy for permanent teeth with carious pulp exposure: A systematic review and meta-analysis of… 2024 All outcomes
>=12 months
OR 6.03 [0.97, 37.6]
2 studies
GRADE not reported

Mineral trioxide aggregate (MTA) vs Calcium hydroxide (CH)

Overall success (composite of clinical and radiographic success) · Permanent teeth with carious pulp exposure

In partial pulpotomy, MTA had significantly higher success than calcium hydroxide (OR 2.81; ungraded).

4 findings from 1 review · compare the 2 reviews

Efficacy of pulpotomy for permanent teeth with carious pulp exposure: A systematic review and meta-analysis of… 2024 All outcomes
>=12 months · Partial pulpotomy
OR 2.81 [1.38, 5.74]
Studies not reported
GRADE not reported
Efficacy of pulpotomy for permanent teeth with carious pulp exposure: A systematic review and meta-analysis of… 2024 All outcomes
>=12 months · Mature teeth
OR 2.63 [1.14, 6.03]
Studies not reported
GRADE not reported
Efficacy of pulpotomy for permanent teeth with carious pulp exposure: A systematic review and meta-analysis of… 2024 All outcomes
>=12 months
OR 2.41 [1.28, 4.51]
7 studies · 377 participants
Low

Show 1 more finding

Efficacy of pulpotomy for permanent teeth with carious pulp exposure: A systematic review and meta-analysis of… 2024 All outcomes
>=12 months · Irreversible pulpitis
OR 3.17 [1.25, 7.99]
Studies not reported
GRADE not reported

Mineral trioxide aggregate (MTA) vs Biodentine

Overall success (composite of clinical and radiographic success) · Permanent teeth with carious pulp exposure

MTA and Biodentine have similar pulpotomy success (OR 0.89, not significant; low certainty).

1 finding from 1 review

Efficacy of pulpotomy for permanent teeth with carious pulp exposure: A systematic review and meta-analysis of… 2024 All outcomes
>=12 months
OR 0.89 [0.47, 1.69]
6 studies · 348 participants
Low

Mineral trioxide aggregate (MTA) vs TotalFill BC

Overall success (composite of clinical and radiographic success) · Permanent teeth with carious pulp exposure

MTA and TotalFill BC had comparable pulpotomy success (ungraded).

1 finding from 1 review

Efficacy of pulpotomy for permanent teeth with carious pulp exposure: A systematic review and meta-analysis of… 2024 All outcomes
>=12 months
OR 1.44 [0.65, 3.19]
2 studies · 248 participants
GRADE not reported

Platelet-rich fibrin (PRF) graft vs Calcium hydroxide (CH)

Overall success (composite of clinical and radiographic success) · Mature permanent teeth with irreversible pulpitis and carious pulp exposure (treated with full pulpotomy)

Platelet-rich fibrin and calcium hydroxide showed no significant difference in success (ungraded; effect size not reported).

1 finding from 1 review

Efficacy of pulpotomy for permanent teeth with carious pulp exposure: A systematic review and meta-analysis of… 2024 All outcomes
>=12 months
OR 1.67 [0.59, 4.72]
2 studies · 70 participants
GRADE not reported

Mineral trioxide aggregate (MTA) vs Calcium-enriched mixture (CEM)

Overall success (composite of clinical and radiographic success) · Permanent teeth with carious pulp exposure

MTA and calcium-enriched mixture had comparable pulpotomy success (ungraded).

1 finding from 1 review

Efficacy of pulpotomy for permanent teeth with carious pulp exposure: A systematic review and meta-analysis of… 2024 All outcomes
>=12 months
OR 0.78 [0.46, 1.34]
4 studies · 611 participants
GRADE not reported

Mineral trioxide aggregate (MTA) vs Platelet-rich fibrin (PRF)

Overall success (composite of clinical and radiographic success) · Permanent teeth with carious pulp exposure

MTA and platelet-rich fibrin had comparable pulpotomy success (ungraded).

1 finding from 1 review

Efficacy of pulpotomy for permanent teeth with carious pulp exposure: A systematic review and meta-analysis of… 2024 All outcomes
>=12 months
OR 1.02 [0.43, 2.43]
3 studies · 109 participants
GRADE not reported