What do systematic reviews say?

5 questions · 5 findings · 2 reviews · Periodontology · related questions CL0289

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No studies found 0 · 0%GRADE not reported 3 · 60%Very low 0 · 0%Low 2 · 40%Moderate 0 · 0%High 0 · 0%

Enamel matrix derivative (EMD; Emdogain) vs Guided tissue regeneration (GTR) with barriers

Change in probing pocket depth (PPD) · Patients affected by chronic, aggressive, or early onset periodontitis, with intrabony defects having an intrabony component of at least 3…

Enamel matrix derivative (EMD; Emdogain) showed no clear difference in change in probing pocket depth (PPD) compared with guided tissue regeneration (GTR) with barriers (low certainty).

1 finding from 1 review

Enamel matrix derivative (Emdogain®) for periodontal tissue regeneration in intrabony defects 2009 · Cochrane All outcomes
1 year (time-points 1, 5 and 10 years planned)
MD -0.4 [-1.1, 0.2]
6 studies · 304 participants
Low

Enamel matrix derivative (EMD; Emdogain) vs placebo or control

Change in probing pocket depth (PPD) · Patients affected by chronic, aggressive, or early onset periodontitis, with intrabony defects having an intrabony component of at least 3…

Enamel matrix derivative (EMD; Emdogain) may leads to higher change in probing pocket depth (PPD) compared with placebo or control (same surgical or non-surgical intervention… (low certainty).

1 finding from 1 review

Enamel matrix derivative (Emdogain®) for periodontal tissue regeneration in intrabony defects 2009 · Cochrane All outcomes
1 year (time-points 1, 5 and 10 years planned)
MD 0.88 [0.44, 1.31]
9 studies · 371 participants
Low

Enamel matrix derivative (EMD; Emdogain) vs Various bone grafting (BG) procedures (animal-derived or synthetic bone / bioactive ceramic filler)

Change in probing pocket depth (PPD) · Patients affected by chronic, aggressive, or early onset periodontitis, with intrabony defects having an intrabony component of at least 3…

1 finding from 1 review

Enamel matrix derivative (Emdogain®) for periodontal tissue regeneration in intrabony defects 2009 · Cochrane All outcomes
1 year (time-points 1, 5 and 10 years planned)
No statistically significant differences (one trial, Leknes 2009).
1 study
GRADE not reported

Occlusal adjustment as an adjunct to non-surgical periodontal therapy vs Non-surgical periodontal therapy alone (no occlusal adjustment)

Change in probing pocket depth (PPD) · Adults with chronic periodontitis

Occlusal adjustment as an adjunct to non-surgical periodontal therapy showed no clear difference in probing (pocket) depth change (difference in mean reduction, mm) compared with non-surgical periodontal therapy alone (no occlusal adjustment); GRADE not reported.

1 finding from 1 review

Occlusal interventions for periodontitis in adults 2008 · Cochrane All outcomes
2 years
MD 0.04 [-0.19, 0.27]
1 study · 50 participants
GRADE not reported

Occlusal adjustment as an adjunct to surgical periodontal therapy vs Surgical periodontal therapy alone (no occlusal adjustment)

Change in probing pocket depth (PPD) · Adults with chronic periodontitis

Occlusal adjustment as an adjunct to surgical periodontal therapy showed no clear difference in probing (pocket) depth change (difference in mean reduction, mm) compared with surgical periodontal therapy alone (no occlusal adjustment); GRADE not reported.

1 finding from 1 review

Occlusal interventions for periodontitis in adults 2008 · Cochrane All outcomes
2 years
MD 0.01 [-0.20, 0.22]
1 study · 50 participants
GRADE not reported