What do systematic reviews say?

3 questions · 3 findings · 1 reviews · Oral medicine and oral cancer · related questions CL0289

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No studies found 0 · 0%GRADE not reported 3 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Tacrolimus 0.1% vs Topical clobetasol propionate 0.05% ointment

Pain reduction (VAS 0-10) · People with erosive oral lichen planus

Topical tacrolimus 0.1% ointment showed no clear difference in pain reduction (VAS 0-10) compared with topical clobetasol propionate 0.05% ointment; GRADE not reported.

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
MD -0.64 [-1.91, 0.63]
1 study · 29 participants
GRADE not reported

Tacrolimus 0.1% vs Topical clobetasol propionate 0.05% ointment

Side effects · People with erosive oral lichen planus

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
Table 3 (Side-effects). Radfar 2008: burning sensation with topical tacrolimus; transient burning within the first 2 weeks resulted in withdrawal of therapy in 1 participant.
1 study · 29 participants
GRADE not reported

Tacrolimus 0.1% vs Topical clobetasol propionate 0.05% ointment

Reduction in target/mean lesion size · People with erosive oral lichen planus

Topical tacrolimus 0.1% ointment showed no clear difference in reduction in target/mean lesion size compared with topical clobetasol propionate 0.05% ointment; GRADE not reported.

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
MD 0.00 [-1.09, 1.10]
1 study · 29 participants
GRADE not reported