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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
13 questions in 6 reviews · cluster CL0287
current versionsNo studies 2 · 15.4%Ungraded 11 · 84.6%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Intervention categories, outcome domains and clusters are a proposed key pending human validation. Clear all filters
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Microinvasive technique (proximal sealing) vs No intervention Radiographic progression of proximal caries lesions · Children with lesions in both primary and permanent teeth (ages 8-10) · 3.5 years, Both permanent and primary (Fig. 6, subgroup 2.1.3) Microinvasive interventions in the management of proximal caries lesions in primary and permanent teeth-… (2025) | OR 0.16 [0.06, 0.44] | 1 study · 61 participants | Ungraded |
Orthodontic adhesives containing bioactive glass (BAG) particles/nanoparticles (including Ag-, Zn-, fluoride-, or Ga-doped BAG) vs Conventional/control orthodontic adhesive (e.g., Transbond XT) or negative control Enamel remineralization / anti-demineralization extent · Human enamel specimens around orthodontic brackets (in vitro) · pH cycling 14 days to 6 months (majority 14 days), Overall Remineralization and anti-demineralization effect of orthodontic adhesives on enamel surrounding orthodontic… (2024) | Out of 13 studies that evaluated bioactive glass particles/nanoparticles, 9 reported definitive statistically significant remineralization potential compared to control orthodontic adhesives [17, 21-24, 26-28, 31]; one… | 13 studies | Ungraded |
Remineralizing orthodontic adhesives vs Control orthodontic adhesives Enamel remineralization or anti-demineralization · Human teeth with early enamel lesions surrounding orthodontic brackets · 5 days to 6 months Remineralization and anti-demineralization effect of orthodontic adhesives on enamel surrounding orthodontic… (2024) | no estimate extracted | 24 studies | Ungraded |
Experimental adhesive containing ammonium-based methacrylate monomer (MADQUAT) vs Conventional/control orthodontic adhesive (e.g., Transbond XT) or negative control Enamel remineralization / carious lesion development · Human enamel specimens around orthodontic brackets (in vitro) · biofilm cariogenic challenge 5 days, Overall Remineralization and anti-demineralization effect of orthodontic adhesives on enamel surrounding orthodontic… (2024) | A study using an orthodontic adhesive containing ammonium-based methacrylate showed significant remineralization power compared with control adhesives [37]. | 1 study | Ungraded |
Self-assembling peptide P11-4 vs Control (placebo / no active therapy) Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic… Comparison of therapies of white spot lesions: a systematic review and network meta-analysis. (2023) | SMD -0.56 [-0.96, -0.15] | 4 studies | Ungraded |
Self-assembling peptide P11-4 vs Fluoride varnish (gold standard) Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic… Comparison of therapies of white spot lesions: a systematic review and network meta-analysis. (2023) | SMD -0.31 [-0.71, 0.09] | 5 studies | Ungraded |
Self-assembling peptide P11-4 vs CPP-ACP Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic… Comparison of therapies of white spot lesions: a systematic review and network meta-analysis. (2023) | SMD -0.38 [-0.87, 0.11] | NR | Ungraded |
CPP-ACFP vs Control (placebo / no active therapy) Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic… Comparison of therapies of white spot lesions: a systematic review and network meta-analysis. (2023) | SMD -0.42 [-0.84, 0.00] | 5 studies | Ungraded |
Self-assembling peptide P11-4 vs CPP-ACFP Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic… Comparison of therapies of white spot lesions: a systematic review and network meta-analysis. (2023) | SMD -0.13 [-0.68, 0.42] | 2 studies | Ungraded |
Flowable resin composite vs Fluoride-releasing resin-based sealant Progression of non-cavitated enamel caries · Children who were regular dental attenders with caries-free first or second primary molars (public health service… Sealants for preventing dental caries in primary teeth (2022) · Cochrane | No studies reported this outcome. | 0 studies | No studies |
Tooth bleaching (carbamide or hydrogen peroxide; home or in-office) vs No bleaching (untreated or pH-cycling control) Enamel demineralisation and susceptibility to caries or acid erosion (microhardness, mineral loss) · Permanent teeth / enamel specimens (in vitro) Is Bleaching Effective in Managing Post-orthodontic White-spot Lesions? A Systematic Review. (2020) | Four studies at high risk of bias and one study at moderate risk reached the overall conclusion that neither home- nor in-office bleaching of permanent teeth was associated with an increased susceptibility to… | 5 studies | Ungraded |
Home or in-office bleaching vs No bleaching Caries susceptibility, enamel demineralisation, erosion, or microhardness · Permanent teeth or extracted human teeth with artificial lesions · Varied or not stated Is Bleaching Effective in Managing Post-orthodontic White-spot Lesions? A Systematic Review. (2020) | no estimate extracted | 5 studies | Ungraded |
Stepwise excavation (two-stage caries removal, re-entry after an interval) vs One stage complete caries removal Progression of caries · Patients with carious teeth, affecting any tooth surface(s), in unrestored primary and permanent teeth Operative caries management in adults and children (2013) · Cochrane | None of the eight included studies reported on the primary outcome of progression of caries. | 0 studies | No studies |