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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
12 questions in 6 reviews · cluster CL0168
current versionsNo studies 1 · 8.3%Ungraded 7 · 58.3%Very low 2 · 16.7%Low 2 · 16.7%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Intervention categories, outcome domains and clusters are a proposed key pending human validation. Clear all filters
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Oral health education/promotion (oral hygiene advice plus diet and feeding practice advice) combined with clinical treatment for mother's dentition (basic restorative and preventive; 1 trial included CHX varnish application) vs Standard care Child oral health behaviour · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6… Interventions with pregnant women, new mothers and other primary caregivers for preventing early childhood… (2024) · Cochrane | One trial (Shenoy 2022) reported changes in child oral health behaviours (other data): some benefit in favour of the intervention. | 1 study | Ungraded |
Oral health education/promotion (oral hygiene advice plus diet and feeding practice advice) combined with clinical treatment for mother's dentition (basic restorative and preventive; 1 trial included CHX varnish application) vs Standard care Caries presence in primary teeth · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6… · Children assessed at 18-24 months Interventions with pregnant women, new mothers and other primary caregivers for preventing early childhood… (2024) · Cochrane | RR 0.44 [0.05, 3.95] | 2 studies · 324 participants | Very low |
P11-4 + fluoride varnish vs CPP-ACP Change in lesion metric measured by QLF, laser fluorescence, or lesion area · People or specimens with white spot lesions or early caries lesions · 2 weeks to 36 months Comparison of therapies of white spot lesions: a systematic review and network meta-analysis. (2023) | SMD -0.78 [-1.33, -0.24] | NR | Ungraded |
Sodium fluoride (NaF) varnish, applied every 3 months, plus OHI vs Inactive control (OHI + water) New root carious lesions (caries prevention) · Older adults with root caries (community-dwelling or residential elders) · 36 months, Tan 2010 A systematic review on the effect of silver diamine fluoride for management of dental caries in permanent… (2023) | Prevented Fraction 64 | 1 study · 306 participants | Ungraded |
Resin-based fissure sealant plus fluoride varnish vs Fluoride varnish alone Number of visits to the dentist for repair of sealant or fluoride varnish application · Children and adolescents from the general population, younger than 20 years of age at the start of the study Pit and fissure sealants versus fluoride varnishes for preventing dental decay in the permanent teeth of… (2020) · Cochrane | The study (Splieth 2001) did not measure the number of visits to the dentist for repair of sealant or fluoride varnish application. | 0 studies | No studies |
Resin-based fissure sealant plus fluoride varnish vs Fluoride varnish alone Time taken to apply pit and fissure sealant or fluoride varnish · Children and adolescents from the general population, younger than 20 years of age at the start of the study Pit and fissure sealants versus fluoride varnishes for preventing dental decay in the permanent teeth of… (2020) · Cochrane | Splieth 2001: total time for sealing and resealing two teeth averaged 29 minutes over 2 years (about 17 minutes initial sealants); each fluoride varnish application under 3 minutes (total 9 minutes). | 1 study | Ungraded |
Resin-based fissure sealant plus fluoride varnish vs Fluoride varnish alone Changes from baseline in decayed, missing and filled (DMF) figures at whole-mouth level · Children and adolescents from the general population, younger than 20 years of age at the start of the study · 2 years Pit and fissure sealants versus fluoride varnishes for preventing dental decay in the permanent teeth of… (2020) · Cochrane | Splieth 2001: whole-mouth mean DMFS increased from 0.2 to 0.6 after 1 year and to 1.1 after 2 years; most caries on occlusal surfaces of first permanent molars (50.9%). | 1 study · 92 participants | Ungraded |
Resin-based fissure sealant plus fluoride varnish vs Fluoride varnish alone Dentine caries in permanent molars (yes/no) · Children and adolescents from the general population, younger than 20 years of age at the start of the study · 2 years Pit and fissure sealants versus fluoride varnishes for preventing dental decay in the permanent teeth of… (2020) · Cochrane | OR 0.30 [0.17, 0.55] | 1 study · 92 participants | Very low |
Professionally-applied fluoride varnish (7700 or 10,000 ppm F), every 6 weeks vs Non-fluoride (placebo) varnish Number of participants with new demineralised lesions (DLs) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond) · At debond; follow-up 1.7 years Fluorides for preventing early tooth decay (demineralised lesions) during fixed brace treatment (2019) · Cochrane | RR 0.52 [0.14, 1.93] | 2 studies · 405 participants | Low |
Professionally-applied fluoride varnish (7700 ppm F ammonium fluoride), every 6 weeks vs Non-fluoride (placebo) varnish Number of participants with more severe DLs (score 3 or 4 versus 1 or 2) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond) · At debond; follow-up 1.7 years Fluorides for preventing early tooth decay (demineralised lesions) during fixed brace treatment (2019) · Cochrane | RR 0.46 [0.22, 0.95] | 1 study · 148 participants | Low |
Professionally applied 5% sodium fluoride (NaF) varnish vs Untreated lesions (single-arm before vs after proportion) Remineralisation of early enamel caries (proportion of lesions remineralised) · Children with early enamel caries or white spot lesions Caries remineralisation and arresting effect in children by professionally applied fluoride treatment - a… (2016) | Proportion 0.636 [0.360, 0.912] | 4 studies | Ungraded |
Professionally applied sodium fluoride (NaF) varnish vs No fluoride treatment Dimensional change (size) of early enamel caries lesions · Children with white spot lesions / early enamel caries Caries remineralisation and arresting effect in children by professionally applied fluoride treatment - a… (2016) | One clinical trial (Du 2012) evaluating dimensional change reported that the average size of early enamel caries in children receiving professional NaF therapy was significantly smaller than in those with no fluoride… | 1 study | Ungraded |