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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
24 questions in 1 reviews · cluster CL0123
current versionsNo studies 3 · 12.5%Ungraded 1 · 4.2%Very low 20 · 83.3%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Intervention categories, outcome domains and clusters are a proposed key pending human validation. Clear all filters
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Combined antiretroviral therapy (post-cART) vs Pre-cART (same children, before therapy) Oral candidiasis prevalence · Children and adolescents (<18 years) living with HIV (CLWH) · After vs before cART (within-person), post-cART vs pre-cART Impact of Antiretroviral Therapy on Oral Health among Children Living with HIV: A Systematic Review and… (2022) | OR 0.19 [0.15, 0.25] | NR | Very low |
Antiretroviral therapy (any, including cART) vs No antiretroviral medication (treatment-naive) Parotid hypertrophy prevalence · Children and adolescents (<18 years) living with HIV (CLWH) Impact of Antiretroviral Therapy on Oral Health among Children Living with HIV: A Systematic Review and… (2022) | OR 0.01 [0.00, 0.05] | NR | Very low |
Antiretroviral therapy (any, including cART) vs No antiretroviral medication (treatment-naive) Dental development and maturation · Children and adolescents (<18 years) living with HIV (CLWH) Impact of Antiretroviral Therapy on Oral Health among Children Living with HIV: A Systematic Review and… (2022) | One study (Trigueiro 2010) reported that dental age exceeded chronological age by 5.35 to 14.36 months (SE 3.03 to 15.86) in children on NRTI/PI/NNRTI regimens versus -0.67 months in those without medication; the… | 1 study | Very low |
Antiretroviral therapy (any, including cART) vs No antiretroviral medication (treatment-naive) Oral hygiene status · Children and adolescents (<18 years) living with HIV (CLWH) Impact of Antiretroviral Therapy on Oral Health among Children Living with HIV: A Systematic Review and… (2022) | OR 0.73 [0.13, 4.26] | 0 studies | Ungraded |
Combined antiretroviral therapy (cART) vs Monotherapy or dual antiretroviral therapy Angular cheilitis prevalence · Children and adolescents (<18 years) living with HIV (CLWH) Impact of Antiretroviral Therapy on Oral Health among Children Living with HIV: A Systematic Review and… (2022) | No eligible studies compared angular cheilitis between CLWH on different ART medications. | 0 studies | No studies |
Combined antiretroviral therapy (cART) vs Monotherapy or dual antiretroviral therapy Recurrent oral ulceration prevalence · Children and adolescents (<18 years) living with HIV (CLWH) Impact of Antiretroviral Therapy on Oral Health among Children Living with HIV: A Systematic Review and… (2022) | No significant difference in recurrent oral ulceration between CLWH on cART and those on monotherapy or dual therapy (no numeric estimate reported in the text); 1 study(ies). | 1 study | Very low |
Antiretroviral therapy (any, including cART) vs No antiretroviral medication (treatment-naive) Mucocele prevalence · Children and adolescents (<18 years) living with HIV (CLWH) Impact of Antiretroviral Therapy on Oral Health among Children Living with HIV: A Systematic Review and… (2022) | OR 0.02 [0.00, 1.09] | NR | Very low |
Combined antiretroviral therapy (cART) vs No antiretroviral medication (treatment-naive) Oral candidiasis prevalence · Children and adolescents (<18 years) living with HIV (CLWH) · cART Impact of Antiretroviral Therapy on Oral Health among Children Living with HIV: A Systematic Review and… (2022) | OR 0.35 [0.24, 0.51] | NR | Very low |
Monotherapy or dual antiretroviral therapy vs No antiretroviral medication (treatment-naive) Oral candidiasis prevalence · Children and adolescents (<18 years) living with HIV (CLWH) · monotherapy or dual therapy Impact of Antiretroviral Therapy on Oral Health among Children Living with HIV: A Systematic Review and… (2022) | No significant difference in oral candidiasis prevalence was found between treatment-naive CLWH and those under monotherapy or dual therapy (no numeric estimate reported in the text). | NR | Very low |
Combined antiretroviral therapy (cART) vs Monotherapy or dual antiretroviral therapy Dental development and maturation · Children and adolescents (<18 years) living with HIV (CLWH) Impact of Antiretroviral Therapy on Oral Health among Children Living with HIV: A Systematic Review and… (2022) | No eligible studies compared dental development and maturation between CLWH on different ART medications. | 0 studies | No studies |
Antiretroviral therapy (any, including cART) vs No antiretroviral medication (treatment-naive) Angular cheilitis prevalence · Children and adolescents (<18 years) living with HIV (CLWH) Impact of Antiretroviral Therapy on Oral Health among Children Living with HIV: A Systematic Review and… (2022) | OR 0.58 [0.17, 1.99] | NR | Very low |
Antiretroviral therapy (any, including cART) vs No antiretroviral medication (treatment-naive) Ulcerative stomatitis prevalence · Children and adolescents (<18 years) living with HIV (CLWH) Impact of Antiretroviral Therapy on Oral Health among Children Living with HIV: A Systematic Review and… (2022) | OR 0.03 [0.02, 0.07] | NR | Very low |
Combined antiretroviral therapy (cART) vs Monotherapy or dual antiretroviral therapy Acute necrotising ulcerative periodontitis prevalence · Children and adolescents (<18 years) living with HIV (CLWH) Impact of Antiretroviral Therapy on Oral Health among Children Living with HIV: A Systematic Review and… (2022) | No significant difference in acute necrotising ulcerative periodontitis between CLWH on cART and those on monotherapy or dual therapy (no numeric estimate reported in the text); 1 study(ies). | 1 study | Very low |
Antiretroviral therapy (any, including cART) vs No antiretroviral medication (treatment-naive) Kaposi's sarcoma prevalence · Children and adolescents (<18 years) living with HIV (CLWH) Impact of Antiretroviral Therapy on Oral Health among Children Living with HIV: A Systematic Review and… (2022) | OR 0.00 [0.00, 0.03] | NR | Very low |
Combined antiretroviral therapy (cART) vs Monotherapy or dual antiretroviral therapy Kaposi's sarcoma prevalence · Children and adolescents (<18 years) living with HIV (CLWH) Impact of Antiretroviral Therapy on Oral Health among Children Living with HIV: A Systematic Review and… (2022) | No significant difference in kaposi's sarcoma between CLWH on cART and those on monotherapy or dual therapy (no numeric estimate reported in the text); 1 study(ies). | 1 study | Very low |
Any antiretroviral therapy vs No antiretroviral medication Oral candidiasis prevalence · Children and adolescents living with HIV Impact of Antiretroviral Therapy on Oral Health among Children Living with HIV: A Systematic Review and… (2022) | OR 0.35 [0.19, 0.63] | 7 studies | Very low |
Antiretroviral therapy (any, including cART) vs No antiretroviral medication (treatment-naive) Recurrent oral ulceration prevalence · Children and adolescents (<18 years) living with HIV (CLWH) Impact of Antiretroviral Therapy on Oral Health among Children Living with HIV: A Systematic Review and… (2022) | OR 1.50 [0.72, 3.13] | NR | Very low |
Antiretroviral therapy (any, including cART) vs No antiretroviral medication (treatment-naive) Oral hairy leukoplakia prevalence · Children and adolescents (<18 years) living with HIV (CLWH) Impact of Antiretroviral Therapy on Oral Health among Children Living with HIV: A Systematic Review and… (2022) | OR 2.75 [0.39, 19.43] | NR | Very low |
Combined antiretroviral therapy (cART) vs Monotherapy or dual antiretroviral therapy Chronic herpes simplex infection prevalence · Children and adolescents (<18 years) living with HIV (CLWH) Impact of Antiretroviral Therapy on Oral Health among Children Living with HIV: A Systematic Review and… (2022) | No significant difference in chronic herpes simplex infection between CLWH on cART and those on monotherapy or dual therapy (no numeric estimate reported in the text); 1 study(ies). | 1 study | Very low |
Combined antiretroviral therapy (cART) vs Monotherapy or dual antiretroviral therapy Oral hairy leukoplakia prevalence · Children and adolescents (<18 years) living with HIV (CLWH) Impact of Antiretroviral Therapy on Oral Health among Children Living with HIV: A Systematic Review and… (2022) | No eligible studies compared oral hairy leukoplakia between CLWH on different ART medications. | 0 studies | No studies |
Antiretroviral therapy (any, including cART) vs No antiretroviral medication (treatment-naive) Mucosal hyperpigmentation prevalence · Children and adolescents (<18 years) living with HIV (CLWH) Impact of Antiretroviral Therapy on Oral Health among Children Living with HIV: A Systematic Review and… (2022) | OR 1.79 [0.89, 3.61] | NR | Very low |
Antiretroviral therapy (any, including cART) vs No antiretroviral medication (treatment-naive) Chronic herpes simplex infection prevalence · Children and adolescents (<18 years) living with HIV (CLWH) Impact of Antiretroviral Therapy on Oral Health among Children Living with HIV: A Systematic Review and… (2022) | OR 2.47 [0.88, 6.97] | NR | Very low |
Combined antiretroviral therapy (cART) vs Monotherapy or dual antiretroviral therapy Oral candidiasis prevalence · Children and adolescents (<18 years) living with HIV (CLWH) Impact of Antiretroviral Therapy on Oral Health among Children Living with HIV: A Systematic Review and… (2022) | OR 0.22 [0.16, 0.29] | 4 studies | Very low |
Combined antiretroviral therapy (cART) vs Monotherapy or dual antiretroviral therapy Persistent parotid enlargement prevalence · Children and adolescents (<18 years) living with HIV (CLWH) Impact of Antiretroviral Therapy on Oral Health among Children Living with HIV: A Systematic Review and… (2022) | No significant difference in persistent parotid enlargement between CLWH on cART and those on monotherapy or dual therapy (no numeric estimate reported in the text); 1 study(ies). | 1 study | Very low |