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Search review questions
Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
3 questions in 3 reviews · intervention: Nutritional supplement · outcome domain: Adverse effects/fluorosis
current versionsNo studies 1 · 33.3%Ungraded 2 · 66.7%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Intervention categories, outcome domains and clusters are a proposed key pending human validation. Clear all filters
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Vitamin A or retinoids (systemic or topical; incl. 13-cis-retinoic acid, acitretin) vs Placebo or no treatment Safety of the intervention (adverse effects) · People with a diagnosis of oral leukoplakia · 4 to 12 months Interventions for treating oral leukoplakia to prevent oral cancer (2016) · Cochrane | SoF 1, Safety of the intervention at 4 to 12 months: '3 studies (1 each evaluating topical acitretin, topical 13-cis-retinoic acid, 200,000 IU per week of vitamin A) found no adverse effects. Systemic 13-cis-retinoic… | 4 studies | Ungraded |
Fluoridated milk vs Non-fluoridated milk Adverse effects: dental fluorosis · General population, irrespective of age or level of risk for dental caries Fluoridated milk for preventing dental caries (2015) · Cochrane | No evidence found. (Correspondence with the author (Maslak 2004) confirmed that no adverse effects were reported.) | 0 studies | No studies |
Vitamin B12 (sublingual, 1000 mcg daily for 6 months) vs Placebo Adverse effects · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and… · 6 months Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) (2012) · Cochrane | No adverse events were associated with receiving vitamin B12 or placebo in this study. | 1 study · 58 participants | Ungraded |