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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
4 questions in 1 reviews · intervention: Fluoride toothpaste/dentifrice · outcome domain: Lesion arrest/remineralization
current versionsNo studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 4 · 100%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Intervention categories, outcome domains and clusters are a proposed key pending human validation. Clear all filters
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
10% CPP-ACP cream (+ 900-ppm NaF mouthrinse + 1,000-ppm NaF dentifrice) vs Placebo cream (+ 900-ppm NaF mouthrinse + 1,000-ppm NaF dentifrice) Arrest or reversal of noncavitated facial/lingual carious lesions · Children and adults with noncavitated carious lesions on facial/lingual surfaces (primary and permanent teeth) · 1 mo Nonrestorative Treatments for Caries: Systematic Review and Network Meta-analysis. (2019) | RR 1.28 [0.97, 1.68] | 1 study · 45 participants | Low |
10% CPP-ACP cream (+ 900-ppm NaF mouthrinse + 1,000-ppm NaF dentifrice) vs Placebo cream (+ 900-ppm NaF mouthrinse + 1,000-ppm NaF dentifrice) Arrest or reversal of noncavitated facial/lingual carious lesions · Children and adults with noncavitated carious lesions on facial/lingual surfaces (primary and permanent teeth) · 3 mo Nonrestorative Treatments for Caries: Systematic Review and Network Meta-analysis. (2019) | RR 1.23 [1.06, 1.42] | 1 study · 45 participants | Low |
5,000-ppm F (1.1% NaF) toothpaste or gel vs No treatment Arrest or reversal of noncavitated and cavitated root carious lesions · Adults (including institutionalized/older adults) with noncavitated and cavitated carious lesions on root surfaces… · 3-12 mo Nonrestorative Treatments for Caries: Systematic Review and Network Meta-analysis. (2019) | RR 2.62 [1.49, 4.63] | 7 studies · 1304 participants | Low |
10% CPP-ACP cream (+ 900-ppm NaF mouthrinse + 1,000-ppm NaF dentifrice) vs Placebo cream (+ 900-ppm NaF mouthrinse + 1,000-ppm NaF dentifrice) Arrest or reversal of noncavitated facial/lingual carious lesions · Children and adults with noncavitated carious lesions on facial/lingual surfaces (primary and permanent teeth) · 2 mo Nonrestorative Treatments for Caries: Systematic Review and Network Meta-analysis. (2019) | RR 1.12 [0.93, 1.36] | 1 study · 45 participants | Low |