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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
4 questions in 2 reviews · intervention: Exposure: microbial · outcome domain: Microbiological/plaque
current versionsNo studies 0 · 0%Ungraded 4 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Intervention categories, outcome domains and clusters are a proposed key pending human validation. Clear all filters
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Salivary Actinobacillus level vs Not specified Salivary S. mutans level · Patients with aggressive periodontitis · Overall Association between periodontitis and dental caries: a systematic review and meta-analysis. (2024) | OR 0.08 [0.01, 0.85] | 1 study | Ungraded |
Salivary Actinobacillus level (high) vs Not specified Salivary S. mutans level · Humans with salivary bacteria measured · Overall Association between periodontitis and dental caries: a systematic review and meta-analysis. (2024) | OR 2.39 [1.00, 5.71] | 1 study | Ungraded |
Salivary F. nucleatum level vs Not specified Salivary S. mutans level · Humans with salivary bacteria measured · Overall Association between periodontitis and dental caries: a systematic review and meta-analysis. (2024) | OR 6.03 [1.55, 23.45] | 1 study | Ungraded |
Dental caries (carious oral microbiome) vs Caries-free / healthy oral microbiome Differential microbial abundance / taxa predictive of caries · Individuals providing oral (saliva/supragingival plaque) 16S rRNA microbiome samples; 2016 samples from 19 studies… Meta-analysis of caries microbiome studies can improve upon disease prediction outcomes. (2022) | Mean-decrease-accuracy discriminating taxa: Capnocytophaga HMT-338, Lactobacillus panis, Treponema HMT-230, Bifidobacterium longum, Delftia acidovorans, Staphylococcus schleiferi; higher log2FC in caries: Selenomonas HMT-146, Aggregatibacter actinomycetemcomitans, Actinomyces HMT-896, Treponema HMT-257; Streptococcus not predictive | 19 studies · 2016 participants | Ungraded |