Gap finder
Search review questions
Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
371 questions in 6 reviews · intervention: Exposure: genetic · outcome domain: Caries (unspecified)
current versionsNo studies 0 · 0%Ungraded 371 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Intervention categories, outcome domains and clusters are a proposed key pending human validation. Clear all filters
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
ADGRL2 gene (aggregate gene-based signal, MAGMA) vs Genome-wide gene background (FDR threshold) Dental caries (self-reported history) · Japanese adults (present-study direct-to-consumer genetic testing cohort); self-reported disease cases vs controls · Lifelong (germline genotype), MAGMA gene-based test (present study) Genome-wide association meta-analysis identifies two novel loci associated with dental caries. (2024) | Gene-based association analysis (MAGMA): ADGRL2 was the only gene associated with dental caries at false-discovery-rate q<0.05 (no effect size reported). | 1 study · 45525 participants | Ungraded |
TT genotype vs TC+CC genotypes Dental caries · Children (<18 years) with vs without dental caries · Recessive model (TT vs TC+CC), PCR-RFLP genotyping Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) | OR 1.49 [0.97, 2.27] | NR | Ungraded |
TT+TC genotypes vs CC genotype Dental caries · Children (<18 years) with vs without dental caries · Dominant model (TT+TC vs CC), Caucasian ethnicity Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) | OR 0.84 [0.50, 1.39] | NR | Ungraded |
TT+TC genotypes vs CC genotype Dental caries · Children (<18 years) with vs without dental caries · Dominant model (TT+TC vs CC), Primary dentition Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) | OR 1.25 [0.08, 20.04] | NR | Ungraded |
TT genotype vs TG+GG genotypes Dental caries · Children (<18 years) with vs without dental caries · Recessive model (TT vs TG+GG) Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) | OR 0.93 [0.68, 1.29] | 3 studies · 796 participants | Ungraded |
TT+TC genotypes vs CC genotype Dental caries · Children (<18 years) with vs without dental caries · Dominant model (TT+TC vs CC), PCR-RFLP genotyping Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) | OR 0.70 [0.47, 1.05] | NR | Ungraded |
G allele vs A allele Dental caries · Children (<18 years) with vs without dental caries · Allelic model (G vs A) Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) | OR 1.56 [0.76, 3.24] | 4 studies · 1741 participants | Ungraded |
CC genotype vs CA+AA genotypes Dental caries · Children (<18 years) with vs without dental caries · Recessive model (CC vs CA+AA) Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) | OR 0.87 [0.70, 1.09] | 3 studies · 1327 participants | Ungraded |
T allele vs G allele Dental caries · Children (<18 years) with vs without dental caries · Allelic model (T vs G) Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) | OR 1.00 [0.81, 1.23] | 3 studies · 796 participants | Ungraded |
T allele vs C allele Dental caries · Children (<18 years) with vs without dental caries · Allelic model (T vs C), Permanent dentition Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) | OR 0.90 [0.54, 1.49] | NR | Ungraded |
C allele vs T allele Dental caries · Children (<18 years) with vs without dental caries · Allelic model (C vs T) Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) | OR 1.33 [1.03, 1.71] | 3 studies · 1329 participants | Ungraded |
CC+CT genotypes vs TT genotype Dental caries · Children (<18 years) with vs without dental caries · Dominant model (CC+CT vs TT) Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) | OR 1.87 [1.15, 3.04] | 3 studies · 1329 participants | Ungraded |
AA genotype vs AG+GG genotypes Dental caries · Children (<18 years) with vs without dental caries · Recessive model (AA vs AG+GG) Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) | OR 1.09 [0.70, 1.71] | 3 studies · 855 participants | Ungraded |
TT genotype vs TC+CC genotypes Dental caries · Children (<18 years) with vs without dental caries · Recessive model (TT vs TC+CC), Permanent dentition Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) | OR 1.36 [0.89, 2.08] | NR | Ungraded |
TT+CC (homozygous) genotypes vs TC (heterozygous) genotype Dental caries · Children (<18 years) with vs without dental caries · Over-dominant model (TT+CC vs TC), Real-time quantitative PCR genotyping Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) | OR 1.52 [1.10, 2.10] | NR | Ungraded |
T allele vs C allele Dental caries · Children (<18 years) with vs without dental caries · Allelic model (T vs C), PCR-RFLP genotyping Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) | OR 0.79 [0.60, 1.04] | NR | Ungraded |
AA+AG genotypes vs GG genotype Dental caries · Children (<18 years) with vs without dental caries · Dominant model (AA+AG vs GG) Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) | OR 1.07 [0.59, 1.96] | 3 studies · 855 participants | Ungraded |
CC+CA genotypes vs AA genotype Dental caries · Children (<18 years) with vs without dental caries · Dominant model (CC+CA vs AA) Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) | OR 0.91 [0.55, 1.50] | 3 studies · 1327 participants | Ungraded |
Cdx-2(rs11568820) A allele / genotype vs G allele / reference genotype Dental caries · Children (<18 years) with vs without dental caries · Not meta-analyzed (single study) Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) | Cdx-2(rs11568820) was reported by only one study (Qin 2019; 303 caries, 245 caries-free) and was therefore not subjected to meta-analysis (Results 'Meta-analysis'; Table 6). | 1 study · 548 participants | Ungraded |
T allele vs C allele Dental caries · Children (<18 years) with vs without dental caries · Allelic model (T vs C) Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) | OR 1.01 [0.83, 1.21] | 6 studies · 1986 participants | Ungraded |
TT+TG genotypes vs GG genotype Dental caries · Children (<18 years) with vs without dental caries · Dominant model (TT+TG vs GG) Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) | OR 1.09 [0.76, 1.58] | 3 studies · 796 participants | Ungraded |
T allele vs C allele Dental caries · Children (<18 years) with vs without dental caries · Allelic model (T vs C), Asian ethnicity Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) | OR 0.98 [0.65, 1.50] | NR | Ungraded |
T allele vs C allele Dental caries · Children (<18 years) with vs without dental caries · Allelic model (T vs C), Mixed dentition Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) | OR 0.80 [0.55, 1.15] | NR | Ungraded |
TT+TC genotypes vs CC genotype Dental caries · Children (<18 years) with vs without dental caries · Dominant model (TT+TC vs CC), Real-time quantitative PCR genotyping Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) | OR 0.87 [0.47, 1.61] | NR | Ungraded |
GG genotype vs GA+AA genotypes Dental caries · Children (<18 years) with vs without dental caries · Recessive model (GG vs GA+AA), Zhang 2006 removed, Sensitivity analysis (Zhang 2006 excluded) Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) | OR 0.86 [0.48, 1.54] | 3 studies · 1329 participants | Ungraded |
AA+GG (homozygous) genotypes vs GA (heterozygous) genotype Dental caries · Children (<18 years) with vs without dental caries · Over-dominant model (AA+GG vs GA), Zhang 2006 removed, Sensitivity analysis (Zhang 2006 excluded) Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) | OR 0.85 [0.48, 1.49] | 3 studies · 1329 participants | Ungraded |
Genome-wide common variants (additive dosage; present-study GWAS) vs Genome-wide significance threshold (P<5E-8) Dental caries - genome-wide-significant loci · Japanese adults (present-study cohort: 30,859 dental caries cases / 14,666 controls) · Lifelong (germline genotype), Present-study GWAS (Japanese) Genome-wide association meta-analysis identifies two novel loci associated with dental caries. (2024) | In the present Japanese GWAS, no loci reached genome-wide significance (P<5E-8) for dental caries; several loci reached the suggestive level (P<1E-5). Top-associated variant rs140784657 (intergenic). All 47 lead… | 1 study · 45525 participants | Ungraded |
TT+TC genotypes vs CC genotype Dental caries · Children (<18 years) with vs without dental caries · Dominant model (TT+TC vs CC) Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) | OR 0.75 [0.54, 1.05] | 5 studies · 1606 participants | Ungraded |
TT+CC (homozygous) genotypes vs TC (heterozygous) genotype Dental caries · Children (<18 years) with vs without dental caries · Over-dominant model (TT+CC vs TC), Primary dentition Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) | OR 1.49 [0.97, 2.28] | NR | Ungraded |
TT+TC genotypes vs CC genotype Dental caries · Children (<18 years) with vs without dental caries · Dominant model (TT+TC vs CC), Asian ethnicity Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) | OR 0.69 [0.44, 1.07] | NR | Ungraded |
TT+CC (homozygous) genotypes vs TC (heterozygous) genotype Dental caries · Children (<18 years) with vs without dental caries · Over-dominant model (TT+CC vs TC), Asian ethnicity Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) | OR 1.38 [1.02, 1.87] | NR | Ungraded |
TT+GG (homozygous) genotypes vs TG (heterozygous) genotype Dental caries · Children (<18 years) with vs without dental caries · Over-dominant model (TT+GG vs TG) Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) | OR 0.89 [0.66, 1.20] | 3 studies · 796 participants | Ungraded |
CC genotype vs CT+TT genotypes Dental caries · Children (<18 years) with vs without dental caries · Recessive model (CC vs CT+TT) Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) | OR 1.23 [0.97, 1.55] | 3 studies · 1329 participants | Ungraded |
CC+AA (homozygous) genotypes vs CA (heterozygous) genotype Dental caries · Children (<18 years) with vs without dental caries · Over-dominant model (CC+AA vs CA) Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) | OR 0.91 [0.73, 1.14] | 3 studies · 1327 participants | Ungraded |
GG genotype vs GA+AA genotypes Dental caries · Children (<18 years) with vs without dental caries · Recessive model (GG vs GA+AA) Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) | OR 0.58 [0.26, 1.30] | 4 studies · 1741 participants | Ungraded |
TT+CC (homozygous) genotypes vs TC (heterozygous) genotype Dental caries · Children (<18 years) with vs without dental caries · Over-dominant model (TT+CC vs TC), PCR-RFLP genotyping Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) | OR 1.15 [0.83, 1.60] | NR | Ungraded |
TT genotype vs TC+CC genotypes Dental caries · Children (<18 years) with vs without dental caries · Recessive model (TT vs TC+CC), Caucasian ethnicity Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) | OR 1.05 [0.56, 1.98] | NR | Ungraded |
T allele vs C allele Dental caries · Children (<18 years) with vs without dental caries · Allelic model (T vs C), Primary dentition Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) | OR 1.45 [0.96, 2.18] | NR | Ungraded |
T allele vs C allele Dental caries · Children (<18 years) with vs without dental caries · Allelic model (T vs C), Real-time quantitative PCR genotyping Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) | OR 1.24 [0.96, 1.60] | NR | Ungraded |
TT+CC (homozygous) genotypes vs TC (heterozygous) genotype Dental caries · Children (<18 years) with vs without dental caries · Over-dominant model (TT+CC vs TC), Permanent dentition Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) | OR 1.48 [1.07, 2.03] | NR | Ungraded |
TT genotype vs TC+CC genotypes Dental caries · Children (<18 years) with vs without dental caries · Recessive model (TT vs TC+CC), Real-time quantitative PCR genotyping Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) | OR 0.83 [0.54, 1.29] | NR | Ungraded |
TT genotype vs TC+CC genotypes Dental caries · Children (<18 years) with vs without dental caries · Recessive model (TT vs TC+CC) Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) | OR 1.21 [0.93, 1.56] | 5 studies · 1586 participants | Ungraded |
TT+CC (homozygous) genotypes vs TC (heterozygous) genotype Dental caries · Children (<18 years) with vs without dental caries · Over-dominant model (TT+CC vs TC) Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) | OR 1.33 [1.06, 1.67] | 6 studies · 1986 participants | Ungraded |
AA+GG (homozygous) genotypes vs AG (heterozygous) genotype Dental caries · Children (<18 years) with vs without dental caries · Over-dominant model (AA+GG vs AG) Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) | OR 1.04 [0.64, 1.70] | 3 studies · 855 participants | Ungraded |
TT genotype vs TC+CC genotypes Dental caries · Children (<18 years) with vs without dental caries · Recessive model (TT vs TC+CC), Mixed dentition Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) | OR 0.73 [0.43, 1.24] | NR | Ungraded |
TT+CC (homozygous) genotypes vs TC (heterozygous) genotype Dental caries · Children (<18 years) with vs without dental caries · Over-dominant model (TT+CC vs TC), Mixed dentition Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) | OR 0.85 [0.50, 1.45] | NR | Ungraded |
TT genotype vs TC+CC genotypes Dental caries · Children (<18 years) with vs without dental caries · Recessive model (TT vs TC+CC), Asian ethnicity Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) | OR 1.16 [0.85, 1.60] | NR | Ungraded |
C allele vs A allele Dental caries · Children (<18 years) with vs without dental caries · Allelic model (C vs A) Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) | OR 0.89 [0.70, 1.14] | 3 studies · 1327 participants | Ungraded |
AA+GG (homozygous) genotypes vs GA (heterozygous) genotype Dental caries · Children (<18 years) with vs without dental caries · Over-dominant model (AA+GG vs GA) Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) | OR 0.60 [0.28, 1.25] | 4 studies · 1741 participants | Ungraded |
TT+TC genotypes vs CC genotype Dental caries · Children (<18 years) with vs without dental caries · Dominant model (TT+TC vs CC), Mixed dentition Association of vitamin D receptor gene polymorphisms with caries risk in children: a systematic review and… (2024) | OR 0.81 [0.44, 1.51] | NR | Ungraded |