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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
6 questions in 2 reviews · intervention: Exposure/condition: systemic-oral · outcome domain: Periodontal/gingival
current versionsNo studies 0 · 0%Ungraded 1 · 16.7%Very low 5 · 83.3%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Intervention categories, outcome domains and clusters are a proposed key pending human validation. Clear all filters
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Antiretroviral therapy (any, including cART) vs No antiretroviral medication (treatment-naive) Linear gingival erythema prevalence · Children and adolescents (<18 years) living with HIV (CLWH) Impact of Antiretroviral Therapy on Oral Health among Children Living with HIV: A Systematic Review and… (2022) | OR 1.29 [0.58, 2.88] | NR | Very low |
Antiretroviral therapy (any, including cART) vs No antiretroviral medication (treatment-naive) Acute necrotising ulcerative gingivitis prevalence · Children and adolescents (<18 years) living with HIV (CLWH) Impact of Antiretroviral Therapy on Oral Health among Children Living with HIV: A Systematic Review and… (2022) | OR 0.00 [0.00, 0.02] | NR | Very low |
Antiretroviral therapy (any, including cART) vs No antiretroviral medication (treatment-naive) Periodontal disease prevalence · Children and adolescents (<18 years) living with HIV (CLWH) Impact of Antiretroviral Therapy on Oral Health among Children Living with HIV: A Systematic Review and… (2022) | OR 0.82 [0.46, 1.44] | 2 studies · 250 participants | Very low |
Combined antiretroviral therapy (cART) vs Monotherapy or dual antiretroviral therapy Linear gingival erythema prevalence · Children and adolescents (<18 years) living with HIV (CLWH) Impact of Antiretroviral Therapy on Oral Health among Children Living with HIV: A Systematic Review and… (2022) | No significant difference in linear gingival erythema between CLWH on cART and those on monotherapy or dual therapy (no numeric estimate reported in the text); 1 study(ies). | 1 study | Very low |
Combined antiretroviral therapy (cART) vs Monotherapy or dual antiretroviral therapy Gingivitis prevalence · Children and adolescents (<18 years) living with HIV (CLWH) Impact of Antiretroviral Therapy on Oral Health among Children Living with HIV: A Systematic Review and… (2022) | No significant difference in gingivitis between CLWH on cART and those on monotherapy or dual therapy (no numeric estimate reported in the text); 2 study(ies). | 2 studies | Very low |
GERD/NERD vs Healthy individuals without reflux (controls) Oral mucosa inflammation (gingivitis, periodontitis, mucosal lesions) · Adults with gastroesophageal reflux disease (GERD) or laryngopharyngeal reflux (LPR) Laryngopharyngeal reflux, gastroesophageal reflux and dental disorders: A systematic review. (2020) | Five studies examined gingival/periodontal and mucosal disorders with inconsistent results: some reported more frequent mucosal inflammatory findings in GERD patients (Yoshikawa, Watanabe, Vinesh 25.5% periodontitis,… | 5 studies | Ungraded |