Findings

What do systematic reviews say?

2,079 questions · 2,112 findings · 171 reviews · Eyes and Vision

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No studies found 587 · 27.8%GRADE not reported 95 · 4.5%Very low 446 · 21.1%Low 557 · 26.4%Moderate 361 · 17.1%High 66 · 3.1%

Intervention not reported

Corneal thickness at the thinnest part of the cornea (measured in microns) · people with keratoconus

1 finding from 1 review

Corneal collagen cross‐linking for treating keratoconus 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 94 participants
Very low

Intervention not reported

Absolute spherical equivalent (measured in dioptres) · people with keratoconus

1 finding from 1 review

Corneal collagen cross‐linking for treating keratoconus 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 94 participants
Very low

Intervention not reported

Quality of life · people with keratoconus

The review found no eligible studies for this question.

1 finding from 1 review

Corneal collagen cross‐linking for treating keratoconus 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Adverse effects · people with keratoconus

1 finding from 1 review

Corneal collagen cross‐linking for treating keratoconus 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 3 participants
GRADE not reported

Regular‐dose postoperative 5‐Fluorouracil vs control

Failure at 12 months · participants with glaucoma surgery

Regular‐dose postoperative 5‐Fluorouracil may leads to lower failure at 12 months compared with control (low certainty).

1 finding from 1 review

5‐Fluorouracil for glaucoma surgery 2014 · Cochrane Headline outcomes only
RR 0.39 [0.26, 0.58]
6 studies · 469 participants
Low

Regular‐dose postoperative 5‐Fluorouracil vs control

Complications ‐ hypotonous maculopathy ‐ high risk of failure ‐ not reported · participants with glaucoma surgery

The review found no eligible studies for this question.

1 finding from 1 review

5‐Fluorouracil for glaucoma surgery 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Regular‐dose postoperative 5‐Fluorouracil vs control

Complications ‐ shallow anterior chamber ‐ high risk of failure · participants with glaucoma surgery

Regular‐dose postoperative 5‐Fluorouracil showed no clear difference in complications ‐ shallow anterior chamber ‐ high risk of failure compared with control (moderate certainty).

1 finding from 1 review

5‐Fluorouracil for glaucoma surgery 2014 · Cochrane Headline outcomes only
RR 2.41 [0.88, 6.58]
2 studies · 239 participants
Moderate

Regular‐dose postoperative 5‐Fluorouracil vs control

Complications ‐ epithelial toxicity ‐ high risk of failure · participants with glaucoma surgery

Regular‐dose postoperative 5‐Fluorouracil probably leads to higher complications ‐ epithelial toxicity ‐ high risk of failure compared with control (moderate certainty).

1 finding from 1 review

5‐Fluorouracil for glaucoma surgery 2014 · Cochrane Headline outcomes only
RR 1.25 [1.12, 1.38]
2 studies · 239 participants
Moderate

Regular‐dose postoperative 5‐Fluorouracil vs control

Failure at 12 months ‐ combined surgery · participants with glaucoma surgery

1 finding from 1 review

5‐Fluorouracil for glaucoma surgery 2014 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 118 participants
Very low

Regular‐dose postoperative 5‐Fluorouracil vs control

Intraocular pressure ( · participants with glaucoma surgery

3 findings from 1 review

5‐Fluorouracil for glaucoma surgery 2014 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 118 participants
Low
5‐Fluorouracil for glaucoma surgery 2014 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 112 participants
Low
5‐Fluorouracil for glaucoma surgery 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 26 participants
Moderate

Regular‐dose postoperative 5‐Fluorouracil vs control

Complications ‐ wound leak ‐ combined surgery · participants with glaucoma surgery

Regular‐dose postoperative 5‐Fluorouracil showed no clear difference in complications ‐ wound leak ‐ combined surgery compared with control (low certainty).

1 finding from 1 review

5‐Fluorouracil for glaucoma surgery 2014 · Cochrane Headline outcomes only
RR 0.9 [0.36, 2.23]
2 studies · 118 participants
Low

Regular‐dose postoperative 5‐Fluorouracil vs control

Complications ‐ hypotonous maculopathy ‐ combined surgery ‐ not reported · participants with glaucoma surgery

The review found no eligible studies for this question.

1 finding from 1 review

5‐Fluorouracil for glaucoma surgery 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Regular‐dose postoperative 5‐Fluorouracil vs control

Complications ‐ shallow anterior chamber ‐ combined surgery · participants with glaucoma surgery

1 finding from 1 review

5‐Fluorouracil for glaucoma surgery 2014 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 118 participants
Very low

Regular‐dose postoperative 5‐Fluorouracil vs control

Complications ‐ epithelial toxicity ‐ combined surgery · participants with glaucoma surgery

Regular‐dose postoperative 5‐Fluorouracil may leads to higher complications ‐ epithelial toxicity ‐ combined surgery compared with control (low certainty).

1 finding from 1 review

5‐Fluorouracil for glaucoma surgery 2014 · Cochrane Headline outcomes only
RR 3.04 [1.56, 5.92]
2 studies · 118 participants
Low

Regular‐dose postoperative 5‐Fluorouracil vs control

Failure at 12 months ‐ primary trabeculectomy · participants with glaucoma surgery

Regular‐dose postoperative 5‐Fluorouracil probably leads to lower failure at 12 months ‐ primary trabeculectomy compared with control (moderate certainty).

1 finding from 1 review

5‐Fluorouracil for glaucoma surgery 2014 · Cochrane Headline outcomes only
RR 0.21 [0.06, 0.68]
2 studies · 112 participants
Moderate

Regular‐dose postoperative 5‐Fluorouracil vs control

Mean intraocular pressure · participants with glaucoma surgery

The review found no eligible studies for this question.

1 finding from 1 review

5‐Fluorouracil for glaucoma surgery 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Regular‐dose postoperative 5‐Fluorouracil vs control

Complications ‐ wound leak ‐ primary trabeculectomy · participants with glaucoma surgery

Regular‐dose postoperative 5‐Fluorouracil showed no clear difference in complications ‐ wound leak ‐ primary trabeculectomy compared with control (low certainty).

1 finding from 1 review

5‐Fluorouracil for glaucoma surgery 2014 · Cochrane Headline outcomes only
RR 0.47 [0.04, 4.91]
2 studies · 112 participants
Low

Regular‐dose postoperative 5‐Fluorouracil vs control

Complications ‐ hypotonous maculopathy ‐ primary trabeculectomy · participants with glaucoma surgery

1 finding from 1 review

5‐Fluorouracil for glaucoma surgery 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 62 participants
Moderate

Regular‐dose postoperative 5‐Fluorouracil vs control

Complications ‐ shallow anterior chamber ‐ primary trabeculectomy · participants with glaucoma surgery

Regular‐dose postoperative 5‐Fluorouracil showed no clear difference in complications ‐ shallow anterior chamber ‐ primary trabeculectomy compared with control (low certainty).

1 finding from 1 review

5‐Fluorouracil for glaucoma surgery 2014 · Cochrane Headline outcomes only
RR 0.47 [0.04, 4.91]
2 studies · 112 participants
Low

Regular‐dose postoperative 5‐Fluorouracil vs control

Complications ‐ epithelial toxicity ‐ primary trabeculectomy · participants with glaucoma surgery

Regular‐dose postoperative 5‐Fluorouracil may leads to higher complications ‐ epithelial toxicity ‐ primary trabeculectomy compared with control (low certainty).

1 finding from 1 review

5‐Fluorouracil for glaucoma surgery 2014 · Cochrane Headline outcomes only
RR 5.85 [2.04, 16.83]
2 studies · 112 participants
Low