Multiple pregnancy rate · subfertile women with polycystic ovary syndrome
Metformin showed no clear difference in multiple pregnancy rate (per woman) compared with placebo co‐treatment (low certainty).
1 finding from 1 review
Ongoing pregnancy · subfertile women with polycystic ovary syndrome
Metformin may leads to higher ongoing pregnancy rate (per woman) compared with placebo co‐treatment (low certainty).
1 finding from 1 review
Clinical pregnancy rate · subfertile women with polycystic ovary syndrome
Metformin may leads to higher clinical pregnancy rate (per woman) compared with placebo co‐treatment (low certainty).
1 finding from 1 review
Menstrual regularity at 12 months Laser LOD vs harmonic scalpel N of participants: 34 (1 RCT) · Women with symptoms of PCOS
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Harms: Adhesions at 6 months ‐ LOD vs THL N of participants: 246 (1 RCT) · Women with symptoms of PCOS
It is very uncertain whether LOD changes harms: Adhesions at 6 months ‐ LOD vs THL N of participants: 246 (1… compared with other surgical interventions (very low certainty).
1 finding from 1 review
OR 0.1 [0.05, 0.18]
Studies not reported
Very low
Menstrual regularity at 12 months Laser LOD vs harmonic scalpel N of participants: 34 (1 RCT) · Women with symptoms of PCOS
LOD 4‐5 may leads to higher menstrual regularity at 6 months ‐ LOD 4 ‐ 5 coagulation points… compared with 2 or fewer punctures (low certainty).
2 findings from 1 review
OR 16.04 [4.19, 61.34]
Studies not reported
Low
OR 14 [2.6, 75.41]
Studies not reported
Low
Menstrual regularity ‐ LOD vs unilateral LOD N of participants: 104 (2 RCTs) · Women with symptoms of PCOS
LOD 4‐5 may leads to higher menstrual regularity at 6 months ‐ LOD (4 ‐ 5 laser coagulation… compared with 2 or fewer punctures (low certainty).
1 finding from 1 review
OR 19 [2.12, 170.38]
Studies not reported
Low
Improvement in androgenic symptoms · Women with symptoms of PCOS
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Harms LOD 4 ‐ 5 versus fewer punctures · Women with symptoms of PCOS
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Menstrual regularity ‐ LOD vs unilateral LOD N of participants: 104 (2 RCTs) · Women with symptoms of PCOS
It is very uncertain whether LOD changes menstrual regularity at 6 months ‐ LOD vs adjusted thermal dose N of… compared with LOD variable energy (very low certainty).
1 finding from 1 review
OR 0.42 [0.16, 1.14]
Studies not reported
Very low
Menstrual regularity at 12 months Laser LOD vs harmonic scalpel N of participants: 34 (1 RCT) · Women with symptoms of PCOS
It is very uncertain whether LOD changes menstrual regularity at 3 months ‐ LOD unipolar vs LOD bipolar N of… compared with LOD variable energy (very low certainty).
1 finding from 1 review
OR 1 [0.05, 18.57]
Studies not reported
Very low
Improvement in androgenic symptoms · Women with symptoms of PCOS
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Harms: Adhesions at 6 months ‐ LOD vs THL N of participants: 246 (1 RCT) · Women with symptoms of PCOS
It is very uncertain whether LOD changes harms: Adhesions at 6 months № of participants: 64 (1 study) compared with LOD variable energy (very low certainty).
1 finding from 1 review
OR 0.96 [0.32, 2.88]
Studies not reported
Very low
Improvement in androgenic symptoms · Women with symptoms of PCOS
LOD showed no clear difference in improvement in androgenic symptoms at 6 months (hirsutism/acne) ‐… compared with medical interventions (low certainty).
2 findings from 1 review
OR 1 [0.42, 2.37]
Studies not reported
Low
OR 3.2 [0.33, 30.94]
Studies not reported
Very low
Harms: GI Upset at 6 months ‐ LOD vs metformin + clomiphene N of participants: 332 (2 RCTs) Harms: OHSS rates at 6 months ‐ LOD vs gonadotrophins N of participants: 33 (1 RCT) · Women with symptoms of PCOS
LOD probably leads to lower harms: GI Upset at 6 months ‐ LOD vs metformin + clomiphene N of… compared with medical interventions (moderate certainty).
1 finding from 1 review
OR 0.05 [0.01, 0.36]
Studies not reported
Moderate
Menstrual regularity ‐ LOD vs unilateral LOD N of participants: 104 (2 RCTs) · Women with symptoms of PCOS
LOD showed no clear difference in menstrual regularity ‐ LOD vs unilateral LOD N of participants: 104… compared with other surgical interventions (moderate certainty).
1 finding from 1 review
OR 1.51 [0.62, 3.71]
Studies not reported
Moderate
Menstrual regularity at 12 months Laser LOD vs harmonic scalpel N of participants: 34 (1 RCT) · Women with symptoms of PCOS
LOD showed no clear difference in menstrual regularity at 6 months ‐ LOD vs ultrasound‐guided… compared with other surgical interventions (low certainty).
2 findings from 1 review
OR 1.23 [0.64, 2.37]
Studies not reported
Low
OR 2.13 [0.17, 26.03]
Studies not reported
Low
Improvement in androgenic symptoms at 6 months (Acne) ‐ LOD vs USS guided N of participants:31 (1 RCT) · Women with symptoms of PCOS
LOD showed no clear difference in improvement in androgenic symptoms at 6 months (Acne) ‐ LOD vs USS… compared with other surgical interventions (low certainty).
1 finding from 1 review
OR 0.84 [0.2, 3.5]
Studies not reported
Low
Improvement in androgenic symptoms at 6 months (Hirsutism) ‐ LOD vs USS‐guided N of participants: 39 (1 RCT) · Women with symptoms of PCOS
LOD showed no clear difference in improvement in androgenic symptoms at 6 months (Hirsutism) ‐ LOD vs… compared with other surgical interventions (low certainty).
1 finding from 1 review
OR 1.09 [0.3, 3.91]
Studies not reported
Low
Prevalence of dysmenorrhoea · women with symptomatic endometriosis
Mifepristone probably leads to lower prevalence of dysmenorrhoea compared with placebo (moderate certainty).
1 finding from 1 review