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What do systematic reviews say?

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Evidence found and GRADE certainty

1,060 questions · 1,105 findings · 84 reviews · Metabolic and Endocrine Disorders

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No studies found 434 · 39.3%GRADE not reported 32 · 2.9%Very low 246 · 22.3%Low 237 · 21.4%Moderate 132 · 11.9%High 24 · 2.2%

Intervention not reported

Potency/bioactivity parameters of human insulin · healthy physicians

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Diabetic ketoacidosis · healthy physicians

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Hypoglycaemic episodes · healthy physicians

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Adverse events · healthy physicians

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Health‐related quality of life · healthy physicians

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

HbA1c · healthy physicians

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Mean fall in plasma glucose levels (mmol/L/min) · healthy physicians
1 finding from 1 review

Intervention not reported

BMI loss (kg/m²) · children and adolescents with obesity

It is very uncertain whether the intervention changes BMI loss (kg/m²) (very low certainty).

1 finding from 1 review

Intervention not reported

Weight loss (kg) · children and adolescents with obesity

It is very uncertain whether the intervention changes weight loss (kg) (very low certainty).

1 finding from 1 review

Intervention not reported

Health‐related quality of life (CHQ (8 subscores); scale 0 to 100, where 0 indicates the worst possible health state and 100 the best possible health state)c Physical functioning Change in health · children and adolescents with obesity

It is very uncertain whether the intervention changes health‐related quality of life (CHQ (8 subscores); scale 0 to 100,… (very low certainty).

1 finding from 1 review

Intervention not reported

All‐cause mortality · children and adolescents with obesity

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Morbidity (metabolic syndrome)d · children and adolescents with obesity

It is very uncertain whether the intervention changes morbidity (metabolic syndrome)d (very low certainty).

1 finding from 1 review