Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

582 questions · 664 findings · 25 reviews · Endodontics and dental trauma

No studies found 111 · 16.7%GRADE not reported 417 · 62.8%Very low 69 · 10.4%Low 50 · 7.5%Moderate 16 · 2.4%High 1 · 0.2%

GIC with cavity conditioner vs GIC without cavity conditioner

Restoration failure · Children with carious primary teeth

No comparative effect estimate was reported; the review states cavity conditioner did not improve success.

1 finding from 1 review

Single-visit root canal treatment vs Multiple-visit root canal treatment (two or more visits)

Postobturation pain at 1 week · People aged 10 years or above requiring root canal treatment; permanent teeth with completely formed apex and without internal resorption

It is very uncertain whether single-visit root canal treatment changes postobturation pain at 1 week compared with multiple-visit root canal treatment (two or more visits) (very low certainty).

1 finding from 1 review

Pulpotomy (full or partial) vs None (single-arm pooled success proportion)

Overall success (composite of clinical and radiographic success) · Human permanent teeth with symptomatic irreversible pulpitis due to carious pulp exposure

In symptomatic irreversible pulpitis, pooled pulpotomy success was 84% (95% CI 72-92%); not significantly different from asymptomatic (z=-1.34, p=0.18); ungraded.

1 finding from 1 review

Amalgam vs Preformed metal crown (PMC)

Treatment failure (annual failure rate) · Children with carious primary molars treated by pulpotomy (vital pulp therapy)

Preformed metal crowns had a low annual failure rate (2.4%) in primary molars after pulpotomy, lower than amalgam in the same trial (single high-risk-of-bias RCT; low quality of evidence; not GRADE-rated).

2 findings from 1 review

HVGIC bilayer insertion and surface coating protocols vs Alternative HVGIC insertion and surface coating protocols

Restoration failure · Children with carious primary teeth

No comparative effect estimate was reported; bilayer placement and nanofilled coating were described as improving survival.

1 finding from 1 review

Single-visit root canal treatment vs Multiple-visit root canal treatment (two or more visits)

Radiological failure (periapical radiolucency) after at least 1 year · People aged 10 years or above requiring root canal treatment; permanent teeth with completely formed apex and without internal resorption

Single-visit root canal treatment showed no clear difference in radiological failure (periapical radiolucency) after at least 1 year compared with multiple-visit root canal treatment (two or more visits) (moderate certainty).

1 finding from 1 review

Super ethoxybenzoic acid (Super-EBA) vs Intermediate restorative material (IRM)

Success rate at 1 year · Patients needing retrograde filling in root canal therapy (orthograde root canal filling or retreatment not possible; periapical surgery…

It is very uncertain whether super ethoxybenzoic acid (Super-EBA) changes success rate at 1 year compared with intermediate restorative material (IRM) (very low certainty).

1 finding from 1 review

Dentine-bonded resin composite vs Glass ionomer cement (GIC)

Success rate at 1 year · Patients needing retrograde filling in root canal therapy (orthograde root canal filling or retreatment not possible; periapical surgery…

It is very uncertain whether dentine-bonded resin composite changes success rate at 1 year (root as unit, per-protocol analysis) compared with glass ionomer cement (very low certainty).

2 findings from 1 review

Mineral trioxide aggregate (MTA) vs Super ethoxybenzoic acid (Super-EBA)

Treatment success rate · Patients needing retrograde filling in root canal therapy (orthograde root canal filling or retreatment not possible; periapical surgery…

Mineral trioxide aggregate (MTA) showed no clear difference in success rate at 4 years compared with super ethoxybenzoic acid (Super-EBA); GRADE not reported.

1 finding from 1 review

Mineral trioxide aggregate (MTA) vs Intermediate restorative material (IRM)

Success rate at 1 year · Patients needing retrograde filling in root canal therapy (orthograde root canal filling or retreatment not possible; periapical surgery…

It is very uncertain whether mineral trioxide aggregate (MTA) changes success rate at 1 year compared with intermediate restorative material (IRM) (very low certainty).

1 finding from 1 review

Mineral trioxide aggregate (MTA) vs Root repair material (RRM)

Success rate at 1 year · Patients needing retrograde filling in root canal therapy (orthograde root canal filling or retreatment not possible; periapical surgery…

It is very uncertain whether mineral trioxide aggregate (MTA) changes success rate at 1 year compared with root repair material (RRM) (very low certainty).

1 finding from 1 review

Mineral trioxide aggregate (MTA) vs Intermediate restorative material (IRM)

Success rate (radiographically‐assessed healing of cyst healing based on the Neer/Cole rating system) · Patients needing retrograde filling in root canal therapy (orthograde root canal filling or retreatment not possible; periapical surgery…

Mineral trioxide aggregate (MTA) showed no clear difference in success rate at 2 years compared with intermediate restorative material (IRM); GRADE not reported.

1 finding from 1 review