Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

671 questions · 731 findings · 61 reviews · Drugs and Alcohol

No studies found 57 · 7.8%GRADE not reported 39 · 5.3%Very low 186 · 25.4%Low 239 · 32.7%Moderate 171 · 23.4%High 39 · 5.3%

Alcoholics Anonymous (AA)/Twelve‐Step Facilitation (TSF) (manualized) vs other clinical interventions

Drinking Intensity · adults (> 18 years) with alcohol use disorder, alcohol abuse, or alcohol dependence
2 findings from 1 review

Alcoholics Anonymous (AA)/Twelve‐Step Facilitation (TSF) (manualized) vs other clinical interventions

Alcohol‐related consequences · adults (> 18 years) with alcohol use disorder, alcohol abuse, or alcohol dependence
2 findings from 1 review

Alcoholics Anonymous (AA)/Twelve‐Step Facilitation (TSF) (manualized) vs other clinical interventions

Addiction Severity Index alcohol score · adults (> 18 years) with alcohol use disorder, alcohol abuse, or alcohol dependence
2 findings from 1 review

Alcoholics Anonymous (AA)/Twelve‐Step Facilitation (TSF) (non‐manualized) vs other clinical interventions

Abstinence · adults (> 18 years) with alcohol use disorder, alcohol abuse, or alcohol dependence

Alcoholics Anonymous (AA)/Twelve‐Step Facilitation (TSF)… showed no clear difference in abstinence compared with other clinical interventions (low certainty).

1 finding from 1 review

Alcoholics Anonymous (AA)/Twelve‐Step Facilitation (TSF) (manualized) vs a different type of TSF

Abstinence · adults (> 18 years) with alcohol use disorder, alcohol abuse, or alcohol dependence

Alcoholics Anonymous (AA)/Twelve‐Step Facilitation (TSF) (manualized) showed no clear difference in abstinence compared with a different type of TSF (moderate certainty).

1 finding from 1 review

Baclofen vs placebo

AW seizures · people with alcohol withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Baclofen vs diazepam

AW seizures · people with alcohol withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Baclofen vs diazepam

AW delirium · people with alcohol withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Baclofen vs diazepam

Global improvement · people with alcohol withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Baclofen vs diazepam

Craving · people with alcohol withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Baclofen vs diazepam

AEs · people with alcohol withdrawal

It is very uncertain whether baclofen changes AEs compared with diazepam (very low certainty).

1 finding from 1 review

Baclofen vs diazepam

Severe AEs · people with alcohol withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Baclofen vs diazepam

Leaving the study early · people with alcohol withdrawal

It is very uncertain whether baclofen changes dropouts compared with diazepam (very low certainty).

1 finding from 1 review

Baclofen vs diazepam

Dropouts due to adverse events · people with alcohol withdrawal

It is very uncertain whether baclofen changes dropouts due to AEs compared with diazepam (very low certainty).

1 finding from 1 review