Findings

What do systematic reviews say?

Refine by population, intervention, comparison or outcome
More filters
Evidence found and GRADE certainty

2,293 questions · 2,395 findings · 172 reviews · Gut

No studies found 420 · 17.5%GRADE not reported 60 · 2.5%Very low 821 · 34.3%Low 602 · 25.1%Moderate 397 · 16.6%High 95 · 4%

Intervention not reported

Induction of remission at 4 weeks · Childen (<16 years old)with active Crohn's disease

The intervention showed no clear difference in induction of remission at 4 weeks (low certainty).

1 finding from 1 review

Briakinumab vs placebo

Failure to induce clinical remission at end of study · induction of remission in Crohn's disease

Briakinumab showed no clear difference in failure to induce clinical remission (Mannon 2004) CDAI (≤150 points) compared with placebo (low certainty).

2 findings from 1 review

Briakinumab vs placebo

Failure to induce clinical response (Panaccione 2010) CDAI ‐ (≥100 point reduction) · induction of remission in Crohn's disease

Briakinumab probably leads to lower failure to induce clinical response (Panaccione 2010) CDAI ‐ (≥100… compared with placebo (moderate certainty).

1 finding from 1 review