Briakinumab vs placebo: Failure to induce clinical remission at end of study
Briakinumab showed no clear difference in failure to induce clinical remission (Mannon 2004) CDAI (≤150 points) compared with placebo (low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Briakinumab vs placebo Failure to induce clinical remission (Mannon 2004) CDAI (≤150 points) · induction of remission in Crohn's disease Briakinumab showed no clear difference in failure to induce clinical remission (Mannon 2004) CDAI (≤150 points) compared with placebo (low certainty). Anti‐IL‐12/23p40 antibodies for induction of remission in Crohn's disease (2016) · Cochrane Headline outcomes only | RR 0.86 [0.65, 1.14] | 1 study · 79 participants | Low |
Briakinumab vs placebo Failure to induce clinical remission (Panaccione 2010) CDAI (≤150 points) · induction of remission in Crohn's disease Briakinumab showed no clear difference in failure to induce clinical remission (Panaccione 2010) CDAI (≤150… compared with placebo (low certainty). Anti‐IL‐12/23p40 antibodies for induction of remission in Crohn's disease (2016) · Cochrane Headline outcomes only | RR 0.92 [0.83, 1.03] | 1 study · 230 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Anti‐IL‐12/23p40 antibodies for induction of remission in Crohn's disease 2016 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.