Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,501 questions · 1,558 findings · 115 reviews · Vascular

No studies found 346 · 22.2%GRADE not reported 90 · 5.8%Very low 281 · 18%Low 477 · 30.6%Moderate 313 · 20.1%High 51 · 3.3%

Intervention not reported

Catheter‐related thrombosis at any time during catheter stay · Children with central venous catheter

The intervention showed no clear difference in catheter‐related thrombosis at any time during catheter stay (moderate certainty).

1 finding from 1 review

Intervention not reported

Catheter‐related blood stream infection and CVC‐related colonization · Children with central venous catheter

The intervention may leads to lower catheter‐related blood stream infection and CVC‐related colonization (low certainty).

1 finding from 1 review

Statins vs placebo

Total VTE · 17,802 patients with low to normal levels of low density lipoprotein (LDL) cholesterol (< 130 mg/dL)

Statin probably leads to lower all cases of VTE compared with placebo (moderate certainty).

1 finding from 1 review

Statins vs placebo

Any MI · 17,802 patients with low to normal levels of low density lipoprotein (LDL) cholesterol (< 130 mg/dL)

Statin probably leads to lower any MI compared with placebo (moderate certainty).

1 finding from 1 review

Statins vs placebo

Stroke · 17,802 patients with low to normal levels of low density lipoprotein (LDL) cholesterol (< 130 mg/dL)

Statin probably leads to lower any stroke compared with placebo (moderate certainty).

1 finding from 1 review

Statins vs placebo

Death · 17,802 patients with low to normal levels of low density lipoprotein (LDL) cholesterol (< 130 mg/dL)

Statin probably leads to lower death compared with placebo (moderate certainty).

1 finding from 1 review

Statins vs placebo

Any serious adverse event · 17,802 patients with low to normal levels of low density lipoprotein (LDL) cholesterol (< 130 mg/dL)

Statin showed no clear difference in any serious adverse event compared with placebo (moderate certainty).

1 finding from 1 review

Knee length vs compression stockings

Deep vein thrombosis · patients with prevention of deep vein thrombosis1

It is very uncertain whether knee length changes deep vein thrombosis (Fixed‐effect analysis) Venous duplex scan,… compared with thigh length graduated compression stockings (very low certainty).

3 findings from 1 review

Direct thrombin inhibitors vs low molecular weight heparin

Major VTE events bilateral ascending venography1 · patients with prevention of venous thromboembolism following total hip or knee replacement

Direct thrombin inhibitors showed no clear difference in major VTE events bilateral ascending venography1 compared with low molecular weight heparins (low certainty).

1 finding from 1 review

Direct thrombin inhibitors vs low molecular weight heparin

All‐cause Mortality events · patients with prevention of venous thromboembolism following total hip or knee replacement

Direct thrombin inhibitors probably leads to higher all‐cause Mortality events compared with low molecular weight heparins (moderate certainty).

1 finding from 1 review

Direct thrombin inhibitors vs low molecular weight heparin

Total Bleeding events · patients with prevention of venous thromboembolism following total hip or knee replacement

Direct thrombin inhibitors showed no clear difference in total Bleeding events compared with low molecular weight heparins (low certainty).

1 finding from 1 review

Direct thrombin inhibitors vs low molecular weight heparin

ALT >3 times the upper normal limit · patients with prevention of venous thromboembolism following total hip or knee replacement

Direct thrombin inhibitors may leads to lower ALT >3 times the upper normal limit compared with low molecular weight heparins (low certainty).

1 finding from 1 review

Direct thrombin inhibitors vs vitamin K antagonist (VKA)

Major VTE events in TKR combined doses bilateral ascending venography · patients with prevention of venous thromboembolism following total hip or knee replacement

Direct thrombin inhibitors showed no clear difference in major VTE events in TKR combined doses bilateral ascending venography compared with vitamin K antagonists (low certainty).

1 finding from 1 review

Direct thrombin inhibitors vs vitamin K antagonist (VKA)

All‐cause Mortality events in TKR combined doses · patients with prevention of venous thromboembolism following total hip or knee replacement

Direct thrombin inhibitors showed no clear difference in all‐cause Mortality events in TKR combined doses compared with vitamin K antagonists (low certainty).

1 finding from 1 review

Direct thrombin inhibitors vs vitamin K antagonist (VKA)

Total Bleeding events in TKR combined doses · patients with prevention of venous thromboembolism following total hip or knee replacement

Direct thrombin inhibitors showed no clear difference in total Bleeding events in TKR combined doses compared with vitamin K antagonists (low certainty).

1 finding from 1 review