Findings

What do systematic reviews say?

2,252 questions · 2,353 findings · 210 reviews · Neonatal

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No studies found 432 · 18.4%GRADE not reported 99 · 4.2%Very low 609 · 25.9%Low 737 · 31.3%Moderate 385 · 16.4%High 91 · 3.9%

Alternative lipid emulsion (LE) vs S‐LE

Death of baby (up to discharge) · Parenterally fed preterm infants

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
GRADE not reported

Alternative lipid emulsion (LE) vs S‐LE

Any ROP – OS‐LE vs S‐LE · Parenterally fed preterm infants

It is very uncertain whether alternative lipid emulsion (LE) changes any ROP – OS‐LE vs S‐LE compared with soybean oil‐based LE (S‐LE) (very low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 0.98 [0.67, 1.43]
3 studies · 142 participants
Very low

Alternative lipid emulsion (LE) vs S‐LE

Bronchopulmonary dysplasia/chronic lung disease · Parenterally fed preterm infants

Alternative lipid emulsion (LE) showed no clear difference in any BPD – OS‐LE vs S‐LE (sensitivity analysis) compared with soybean oil‐based LE (S‐LE) (low certainty).

2 findings from 2 reviews · compare the 2 reviews

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 1.01 [0.57, 1.79]
3 studies · 197 participants
Low
Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
RR 0.84 [0.63, 1.12]
7 studies · 602 participants
Very low

Alternative lipid emulsion (LE) vs S‐LE

Culture‐positive sepsis · Parenterally fed preterm infants

Alternative lipid emulsion (LE) showed no clear difference in culture‐positive sepsis – OS‐LE vs S‐LE compared with soybean oil‐based LE (S‐LE) (low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 1.22 [0.54, 2.78]
2 studies · 164 participants
Low

Alternative lipid emulsion (LE) vs S‐LE

Conjugated bilirubin levels · Parenterally fed preterm infants

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 310 participants
Low

Alternative lipid emulsion (LE) vs another alternative‐LE

Growth · Parenterally fed preterm infants

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 59 participants
Low

Alternative lipid emulsion (LE) vs another alternative‐LE

PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) – MS‐LE vs OS‐LE · Parenterally fed preterm infants

Alternative lipid emulsion (LE) showed no clear difference in PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) – MS‐LE vs OS‐LE compared with another alternative‐LE (low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 2.9 [0.12, 68.5]
1 study · 59 participants
Low

Alternative lipid emulsion (LE) vs another alternative‐LE

Death at hospital discharge · Parenterally fed preterm infants

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
GRADE not reported

Alternative lipid emulsion (LE) vs another alternative‐LE

Oxygen requirement at 36 weeks' postmenstrual age · Parenterally fed preterm infants

Alternative lipid emulsion (LE) showed no clear difference in CLD (oxygen requirement at 36 weeks' postmenstrual age) – MS‐LE vs… compared with another alternative‐LE (low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 0.77 [0.23, 2.6]
1 study · 59 participants
Low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

PNALD/cholestasis (any definition: low and unclear risk of bias studies) – all fish oil LE vs non‐fish oil LE · Parenterally fed preterm infants

Fish oil lipid emulsion (LE) showed no clear difference in PNALD/cholestasis (any definition: low and unclear risk of bias… compared with non‐fish oil LE (low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 0.8 [0.53, 1.21]
10 studies · 1024 participants
Low

Alternative lipid emulsion (LE) vs another alternative‐LE

Any sepsis (clinical and/or culture positive) · Parenterally fed preterm infants

Alternative lipid emulsion (LE) showed no clear difference in any sepsis (clinical or culture positive (or both)) – MS‐LE vs OS‐LE compared with another alternative‐LE (low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 1.93 [0.65, 5.73]
1 study · 59 participants
Low

Alternative lipid emulsion (LE) vs another alternative‐LE

Conjugated bilirubin levels · Parenterally fed preterm infants

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 59 participants
Low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) – pure F‐LE vs S‐LE · parenterally fed preterm infants with surgical conditions

It is very uncertain whether fish oil lipid emulsion (LE) changes PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) – pure F‐LE vs S‐LE compared with non‐fish oil LE (very low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 1.11 [0.08, 15.28]
1 study · 19 participants
Very low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Death at hospital discharge · parenterally fed preterm infants with surgical conditions

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 19 participants
GRADE not reported

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Culture‐positive sepsis · parenterally fed preterm infants with surgical conditions

It is very uncertain whether fish oil lipid emulsion (LE) changes culture‐positive sepsis – pure F‐LE vs S‐LE compared with non‐fish oil LE (very low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 1.11 [0.39, 3.19]
1 study · 19 participants
Very low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Conjugated bilirubin levels · parenterally fed preterm infants with surgical conditions

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 19 participants
Very low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Neurodevelopmental outcomes · parenterally fed preterm infants with surgical conditions

2 findings from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 11 participants
GRADE not reported
Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 10 participants
GRADE not reported

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Resolution of PNALD/ cholestasis (conjugated bilirubin < 2 mg/dL) Pure F‐LE vs Intralipid · parenterally fed preterm infants with cholestasis

It is very uncertain whether fish oil lipid emulsion (LE) changes resolution of PNALD/ cholestasis (conjugated bilirubin < 2 mg/dL)… compared with non‐fish oil LE (very low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 5.6 [0.34, 93.35]
1 study · 16 participants
Very low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

PNALD/ cholestasis (any definition) MOFS‐LE vs S‐LE Pure F‐LE vs S‐LE · parenterally fed preterm infants with cholestasis

It is very uncertain whether fish oil lipid emulsion (LE) changes PNALD/ cholestasis (any definition) MOFS‐LE vs S‐LE Pure F‐LE vs S‐LE compared with non‐fish oil LE (very low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 0.54 [0.32, 0.91]
2 studies · 40 participants
Very low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

PNALD/cholestasis (any definition): combined subgroups (all studies) – all fish oil LE vs non‐fish oil LE · Parenterally fed preterm infants

It is very uncertain whether fish oil lipid emulsion (LE) changes PNALD/cholestasis (any definition): combined subgroups (all studies)… compared with non‐fish oil LE (very low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 0.63 [0.43, 0.91]
11 studies · 1154 participants
Very low