Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,923 questions · 1,956 findings · 143 reviews · Musculoskeletal

No studies found 555 · 28.4%GRADE not reported 107 · 5.5%Very low 255 · 13%Low 555 · 28.4%Moderate 357 · 18.3%High 127 · 6.5%

MTX treated vs no MTX treated

Withdrawals due to any reason · Patients with AS

MTX treated showed no clear difference in withdrawal for any reason compared with no MTX treated (low certainty).

1 finding from 1 review

Intervention not reported

ACR50 American College of Rheumatology 50% improvement criteria · participants with rheumatoid arthritis and with a partial response to DMARDs

The intervention probably leads to higher ACR50 American College of Rheumatology 50% improvement criteria (moderate certainty).

1 finding from 1 review

Intervention not reported

Reduction in disability score Health Assessment Questionnaire (mean improvement from baseline). Scale from: 0 to 3 · participants with rheumatoid arthritis and with partial response to MTX
1 finding from 1 review

Intervention not reported

Radiographic progression Total Sharp Score · participants with rheumatoid arthritis and with partial response to MTX
1 finding from 1 review

Intervention not reported

Withdrawals due to adverse events · participants with rheumatoid arthritis and with partial response to MTX

The intervention showed no clear difference in withdrawals due to adverse events (moderate certainty).

1 finding from 1 review

Intervention not reported

Serious adverse events · participants with rheumatoid arthritis and with partial response to MTX

The intervention showed no clear difference in serious adverse events (moderate certainty).

1 finding from 1 review

Intervention not reported

Serious infections · participants with rheumatoid arthritis and with partial response to MTX
1 finding from 1 review

Intervention not reported

Etanercept (25 mg) + DMARD · participants with rheumatoid arthritis

The intervention leads to higher etanercept (25 mg) + DMARD (high certainty).

1 finding from 1 review

Intervention not reported

Etanercept (10 mg) · participants with rheumatoid arthritis

The intervention leads to lower etanercept (10 mg) (high certainty).

1 finding from 1 review

Intervention not reported

Etanercept (25 mg) · participants with rheumatoid arthritis

The intervention leads to higher etanercept (25 mg) (high certainty).

1 finding from 1 review

Intervention not reported

Serious infections · participants with rheumatoid arthritis

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Outcome: ACR50 ‐ American College of Rheumatology Improvement Criteria · participants with rheumatoid arthritis

The review found no eligible studies for this question.

1 finding from 1 review