Health‐related quality of life Mean AcroQoL score (0‐100) · adults with growth‐hormone secreting pituitary adenomas
Surgery alone showed no clear difference in health‐related quality of life Mean AcroQoL score (0‐100) compared with pharmacological therapy alone (low certainty).
1 finding from 1 review
Disease‐related complications Intubation difficulties requiring postponement of surgery · adults with growth‐hormone secreting pituitary adenomas
It is very uncertain whether surgery alone changes disease‐related complications Intubation difficulties requiring… compared with preoperative pharmacological therapy and surgery (very low certainty).
1 finding from 1 review
Recurrence · adults with growth‐hormone secreting pituitary adenomas
1 finding from 1 review
Frequency of pain crises in the · adults with sickle cell disease (adults with homozygous SCA or sickle beta 0 thalassaemia SCD)
It is very uncertain whether vitamin C 1400 mg plus vitamin E 800 mg changes frequency of pain crisis compared with placebo (very low certainty).
1 finding from 1 review
QoL of participants living with SCD and their caregivers · people with sickle cell disease
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Adverse effects · people with sickle cell disease
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Frequency of hospitalization · people with sickle cell disease
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Frequency of sickle cell‐related complications: number of participants with completely healed leg ulcer ( · people with sickle cell disease
It is very uncertain whether zinc changes frequency of sickle cell‐related complications: number of… compared with placebo (very low certainty).
1 finding from 1 review
Haemoglobin status · people with sickle cell disease
Zinc may leads to higher haemoglobin status (g/dL) compared with placebo (low certainty).
1 finding from 1 review
Frequency of crisis (number of pain days) · sickle cell disease
N‐acetylcysteine (1200 mg) showed no clear difference in frequency of crisis (number of pain days) compared with placebo (low certainty).
1 finding from 1 review
Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · sickle cell disease
N‐acetylcysteine (1200 mg) showed no clear difference in severity of pain (maximum pain intensity on pain days) compared with placebo (low certainty).
1 finding from 1 review
QoL of participants living with SCD and their caregivers · sickle cell disease
It is very uncertain whether N‐acetylcysteine (1200 mg) changes qoL of participants living with SCD and their caregivers (measured… compared with placebo (very low certainty).
1 finding from 1 review
Adverse effects · sickle cell disease
N‐acetylcysteine (1200 mg) showed no clear difference in adverse effects compared with placebo (low certainty).
1 finding from 1 review
Frequency of hospitalization · sickle cell disease
N‐acetylcysteine (1200 mg) may leads to lower frequency of hospitalization compared with placebo (low certainty).
1 finding from 1 review
Severity of pain (use of opioid analgesics) · adults with sickle cell disease (adults with homozygous SCA or sickle beta 0 thalassaemia SCD)
It is very uncertain whether vitamin C 1400 mg plus vitamin E 800 mg changes severity of pain (use of opioid analgesics) compared with placebo (very low certainty).
1 finding from 1 review
Acute chest syndrome ( · sickle cell disease
It is very uncertain whether N‐acetylcysteine (1200 mg) changes frequency of sickle cell‐related complications (acute chest syndrome) compared with placebo (very low certainty).
1 finding from 1 review
Haemoglobin status · sickle cell disease
N‐acetylcysteine (1200 mg) showed no clear difference in haemoglobin status compared with placebo (low certainty).
1 finding from 1 review
Frequency of crisis · sickle cell disease
L‐arginine showed no clear difference in frequency of crisis (monthly crisis) compared with placebo (low certainty).
1 finding from 1 review
Pain 0 to 100 visual analogue scale and 10‐point Likert scale (lower score = less pain) · sickle cell disease
L‐arginine showed no clear difference in severity of pain (assessed using a 10‐cm visual analogue scale from… compared with placebo (low certainty).
1 finding from 1 review
QoL of participants living with SCD and their caregivers · sickle cell disease
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found