What do systematic reviews say?

Psychological therapies vs benzodiazepines

It is very uncertain whether all psychological therapies changes dropouts for any reason compared with benzodiazepines (very low certainty).

• Psychological therapies versus pharmacological interventions for panic disorder with or without agoraphobia in adults 2016 · Cochrane Headline outcomes only
  RR 1.12 [0.54, 2.36]
  3 studies · 116 participants
  Very low

Psychological therapies vs benzodiazepines

• Psychological therapies versus pharmacological interventions for panic disorder with or without agoraphobia in adults 2016 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Psychological therapies vs SSRI

It is very uncertain whether all psychological therapies changes short‐term response compared with SSRI (very low certainty).

• Psychological therapies versus pharmacological interventions for panic disorder with or without agoraphobia in adults 2016 · Cochrane Headline outcomes only
  RR 0.97 [0.51, 1.86]
  5 studies · 277 participants
  Very low

Psychological therapies vs benzodiazepines

• Psychological therapies versus pharmacological interventions for panic disorder with or without agoraphobia in adults 2016 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 89 participants
  Very low

Psychological therapies vs antidepressants alone or antidepressants and benzodiazepines

All psychological therapies showed no clear difference in short‐term remission compared with antidepressants alone or antidepressants and benzodiazepines (low certainty).

• Psychological therapies versus pharmacological interventions for panic disorder with or without agoraphobia in adults 2016 · Cochrane Headline outcomes only
  RR 0.86 [0.71, 1.05]
  11 studies · 663 participants
  Low

Psychological therapies vs antidepressants alone or antidepressants and benzodiazepines

All psychological therapies showed no clear difference in short‐term response compared with antidepressants alone or antidepressants and benzodiazepines (low certainty).

• Psychological therapies versus pharmacological interventions for panic disorder with or without agoraphobia in adults 2016 · Cochrane Headline outcomes only
  RR 0.95 [0.76, 1.18]
  12 studies · 800 participants
  Low

Psychological therapies vs antidepressants alone or antidepressants and benzodiazepines

It is very uncertain whether all psychological therapies changes dropouts for any reason compared with antidepressants alone or antidepressants and benzodiazepines (very low certainty).

• Psychological therapies versus pharmacological interventions for panic disorder with or without agoraphobia in adults 2016 · Cochrane Headline outcomes only
  RR 1.08 [0.77, 1.51]
  13 studies · 909 participants
  Very low

Psychological therapies vs antidepressants alone or antidepressants and benzodiazepines

• Psychological therapies versus pharmacological interventions for panic disorder with or without agoraphobia in adults 2016 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Psychological therapies vs antidepressants alone or antidepressants and benzodiazepines

• Psychological therapies versus pharmacological interventions for panic disorder with or without agoraphobia in adults 2016 · Cochrane Headline outcomes only
  no estimate extracted
  11 studies · 638 participants
  Low

Psychological therapies vs SSRI

All psychological therapies showed no clear difference in dropouts for any reason compared with SSRI (low certainty).

• Psychological therapies versus pharmacological interventions for panic disorder with or without agoraphobia in adults 2016 · Cochrane Headline outcomes only
  RR 1.33 [0.8, 2.22]
  6 studies · 334 participants
  Low

Psychological therapies vs SSRI

• Psychological therapies versus pharmacological interventions for panic disorder with or without agoraphobia in adults 2016 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Psychological therapies vs SSRI

• Psychological therapies versus pharmacological interventions for panic disorder with or without agoraphobia in adults 2016 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 242 participants
  Moderate

Psychological therapies vs tricyclic antidepressants (TCAs)

All psychological therapies showed no clear difference in short‐term remission compared with tricyclic antidepressants (low certainty).

• Psychological therapies versus pharmacological interventions for panic disorder with or without agoraphobia in adults 2016 · Cochrane Headline outcomes only
  RR 0.82 [0.62, 1.09]
  3 studies · 229 participants
  Low

Psychological therapies vs tricyclic antidepressants (TCAs)

All psychological therapies showed no clear difference in short‐term response compared with tricyclic antidepressants (low certainty).

• Psychological therapies versus pharmacological interventions for panic disorder with or without agoraphobia in adults 2016 · Cochrane Headline outcomes only
  RR 0.75 [0.51, 1.1]
  4 studies · 270 participants
  Low

Psychological therapies vs tricyclic antidepressants (TCAs)

All psychological therapies showed no clear difference in dropouts for any reason compared with tricyclic antidepressants (low certainty).

• Psychological therapies versus pharmacological interventions for panic disorder with or without agoraphobia in adults 2016 · Cochrane Headline outcomes only
  RR 0.83 [0.53, 1.3]
  5 studies · 430 participants
  Low

Psychological therapies vs tricyclic antidepressants (TCAs)

• Psychological therapies versus pharmacological interventions for panic disorder with or without agoraphobia in adults 2016 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

S‐adenosyl methionine as monotherapy vs placebo

• S‐adenosyl methionine (SAMe) for depression in adults 2016 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 142 participants
  Very low

S‐adenosyl methionine as monotherapy vs tricyclic antidepressants (TCAs)

S‐adenosyl methionine as monotherapy may leads to lower acceptability. Participants experiencing troublesome adverse effects… compared with tricyclic antidepressant agent (low certainty).

• S‐adenosyl methionine (SAMe) for depression in adults 2016 · Cochrane Headline outcomes only
  RR 0.68 [0.52, 0.88]
  3 studies · 604 participants
  Low

S‐adenosyl methionine as monotherapy vs SSRI

• S‐adenosyl methionine (SAMe) for depression in adults 2016 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 129 participants
  Low

S‐adenosyl methionine as monotherapy vs SSRI

S‐adenosyl methionine as monotherapy showed no clear difference in acceptability Participants dropping out of treatment during the… compared with SSRI antidepressant agent (low certainty).

• S‐adenosyl methionine (SAMe) for depression in adults 2016 · Cochrane Headline outcomes only
  RR 0.81 [0.57, 1.16]
  1 study · 129 participants
  Low