Live birth rate per woman aParticipants with BMI ≥ 30 kg/m2 · women with polycystic ovary syndrome
It is very uncertain whether metformin changes live birth rate per woman aParticipants with BMI ≥ 30 kg/m2 compared with clomiphene citrate (very low certainty).
Gastrointestinal adverse events · women with polycystic ovary syndrome
The review found no eligible studies for this question.
no estimate extracted
Studies not reported
No studies found
no estimate extracted
Studies not reported
No studies found
Clinical pregnancy rate per woman Participants with BMI < 30 kg/m2 or ≤ 32 kg/m2a · women with polycystic ovary syndrome
Metformin may leads to higher clinical pregnancy rate per womanaParticipants with BMI < 30 kg/m2… compared with clomiphene citrate (low certainty).
Clinical pregnancy rate per woman aParticipants with BMI ≥ 30 kg/m2 · women with polycystic ovary syndrome
Metformin may leads to lower clinical pregnancy rate per woman aParticipants with BMI ≥ 30 kg/m2 compared with clomiphene citrate (low certainty).
Ovulation rate per woman fParticipants with BMI < 30 kg/m2 · women with polycystic ovary syndrome
Metformin showed no clear difference in ovulation rate per woman fParticipants with BMI < 30 kg/m2 compared with clomiphene citrate (low certainty).
Ovulation rate per woman fParticipants with BMI ≥ 30 kg/m2 · women with polycystic ovary syndrome
Metformin may leads to lower ovulation rate per woman fParticipants with BMI ≥ 30 kg/m2 compared with clomiphene citrate (low certainty).
Miscarriage rate per woman aParticipants with BMI < 30 kg/2 · women with polycystic ovary syndrome
Metformin showed no clear difference in miscarriage rate per woman aParticipants with BMI < 30 kg/2 compared with clomiphene citrate (low certainty).
1 finding from 1 review
Miscarriage rate per woman aParticipants with BMI ≥ 30 kg/m2 · women with polycystic ovary syndrome
Metformin showed no clear difference in miscarriage rate per woman aParticipants with BMI ≥ 30 kg/m2 compared with clomiphene citrate (low certainty).
1 finding from 1 review
Gastrointestinal adverse events · women with polycystic ovary syndrome
Metformin probably leads to higher adverse events (gastrointestinal) per woman compared with placebo or no treatment (moderate certainty).
1 finding from 1 review
Ovulation rate · women with polycystic ovary syndrome
Metformin may leads to higher ovulation rate per woman compared with placebo or no treatment (low certainty).
1 finding from 1 review
Live birth rate per woman · women with polycystic ovary syndrome
Metformin combined with clomiphene citrate showed no clear difference in live birth rate per woman compared with clomiphene citrate alone (low certainty).
Gastrointestinal adverse events · women with polycystic ovary syndrome
Metformin combined with clomiphene citrate probably leads to higher adverse events (gastrointestinal) per woman compared with clomiphene citrate alone (moderate certainty).
Clinical pregnancy rate · women with polycystic ovary syndrome
Metformin combined with clomiphene citrate probably leads to higher clinical pregnancy rate per woman compared with clomiphene citrate alone (moderate certainty).
Ovulation rate · women with polycystic ovary syndrome
Metformin combined with clomiphene citrate may leads to higher ovulation rate per woman compared with clomiphene citrate alone (low certainty).
Menstrual blood loss: mean loss · women with heavy menstrual bleeding
1 finding from 1 review
Menstrual blood loss: improvement rates · women with heavy menstrual bleeding
Antifibrinolytics may leads to higher menstrual blood loss: improvement rates compared with NSAIDs (low certainty).
1 finding from 1 review
Adverse events (any) · women with heavy menstrual bleeding
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Thromboembolic events · women with heavy menstrual bleeding
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Menstrual blood loss: mean loss · women with heavy menstrual bleeding
1 finding from 1 review
Menstrual blood loss: improvement rates · women with heavy menstrual bleeding
It is very uncertain whether antifibrinolytics changes menstrual blood loss: improvement rates compared with ethamsylate (very low certainty).
1 finding from 1 review