Maintenance chemotherapy vs observation
Maintenance chemotherapy showed no clear difference in 5‐year OS compared with observation (moderate certainty).
- RR 1.03 [0.96, 1.1]4 studies · 899 participantsModerate
Maintenance chemotherapy showed no clear difference in 5‐year OS compared with observation (moderate certainty).
Maintenance chemotherapy showed no clear difference in 10‐year OS compared with observation (moderate certainty).
Platin‐based maintenance chemotherapy showed no clear difference in 3‐year PFS compared with observation (moderate certainty).
Interferon + chemotherapy may leads to higher overall survival compared with chemotherapy alone (low certainty).
Interferon showed no clear difference in adverse event (nausea/ vomiting) compared with observation alone (low certainty).
Interferon + chemotherapy may leads to higher progression‐free survival compared with chemotherapy alone (low certainty).
Interferon + chemotherapy showed no clear difference in adverse event (flu‐like symptoms) compared with chemotherapy alone (low certainty).
Interferon + chemotherapy showed no clear difference in adverse event (fatigue) compared with chemotherapy alone (low certainty).
Interferon + chemotherapy showed no clear difference in adverse event (neurotoxicity) compared with chemotherapy alone (low certainty).
Interferon showed no clear difference in overall survival compared with observation alone (low certainty).
Interferon showed no clear difference in progression‐free survival compared with observation alone (low certainty).
Interferon may leads to higher adverse event (flu‐like symptoms) compared with observation alone (low certainty).
Interferon may leads to higher adverse event (fatigue) compared with observation alone (low certainty).
Dietary modification probably leads to lower diarrhoea at end of treatment compared with no nutritional intervention (moderate certainty).
The intervention showed no clear difference in PFS¹ (high certainty).
The intervention showed no clear difference in OS² (high certainty).
The intervention leads to higher anaemia (grade 3/4) (high certainty).
The intervention leads to higher thrombocytopenia (grade 3/4) (high certainty).
The intervention leads to lower alopecia (grade 2) (high certainty).