Change in depressive symptoms · adults with acute affective episodes in bipolar disorder
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Acceptability. Participants experiencing troublesome adverse effects of any nature · adults with acute affective episodes in bipolar disorder
Topiramate showed no clear difference in acceptability with topiramate (endpoint: 12 weeks) Number of… compared with placebo (low certainty).
1 finding from 1 review
Response to treatment with topiramate. Number of participants experiencing a 50% reduction or greater in mean score from baseline to end of treatment on symptom rating scales in manic and mixed episodes · adults with acute affective episodes in bipolar disorder
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
> 50% reduction in depressive symptoms · adults with acute affective episodes in bipolar disorder
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Remission · adults with acute affective episodes in bipolar disorder
The review found no eligible studies for this question.
2 findings from 1 review
no estimate extracted
Studies not reported
No studies found
no estimate extracted
Studies not reported
No studies found
Efficacy: change in scores from baseline to endpoint (12 weeks) on symptom rating scales in the treatment of manic and mixed episodes Lower scores indicate improvement · adults with acute affective episodes in bipolar disorder
1 finding from 1 review
Recurrence · older people in remission from depression
Antidepressant medication may leads to lower recurrence at 12 months compared with placebo at 12 months' follow‐up (low certainty).
1 finding from 1 review
Overall drop‐out rates (excluding deaths) at 12 months · older people in remission from depression
Antidepressant medication showed no clear difference in overall drop‐out rates (excluding deaths) at 12 months compared with placebo at 12 months' follow‐up (low certainty).
1 finding from 1 review
Intervention not reported
PTSD severity following treatment completion As assessed by the CAPS, PSS‐I, or IES‐R. High scores indicate greater symptom severity · Individuals with post‐traumatic stress disorder and comorbid substance use disorder
1 finding from 1 review
Drug or alcohol use, or both following treatment completion ‐ Group‐based intervention As assessed by the ASI, TLFB or CIDI. High scores indicate greater symptom severity · Individuals with post‐traumatic stress disorder and comorbid substance use disorder
1 finding from 1 review
Treatment completers ‐ Individual‐based intervention · Individuals with post‐traumatic stress disorder and comorbid substance use disorder
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Treatment completers ‐ Group‐based intervention · Individuals with post‐traumatic stress disorder and comorbid substance use disorder
Non‐trauma‐focused psychological intervention for PTSD and SUD or… showed no clear difference in treatment completers ‐ Group‐based intervention compared with control intervention (low certainty).
1 finding from 1 review
Severity of PTSD symptoms · Individuals with post‐traumatic stress disorder and comorbid substance use disorder
1 finding from 1 review
Drug or alcohol use, or both following treatment completion ‐ Individual‐based intervention · Individuals with post‐traumatic stress disorder and comorbid substance use disorder
1 finding from 1 review
Treatment completers · Individuals with post‐traumatic stress disorder and comorbid substance use disorder
It is very uncertain whether non‐trauma‐focused psychological intervention for PTSD and SUD or… changes treatment completers compared with active psychological intervention (very low certainty).
1 finding from 1 review
Intervention not reported
Drug or alcohol use, or both following treatment completion As assessed by the TLFB or CIDI. High scores indicate greater symptom severity · Individuals with post‐traumatic stress disorder and comorbid substance use disorder
1 finding from 1 review
Intervention not reported
Treatment completers · Individuals with post‐traumatic stress disorder and comorbid substance use disorder
The intervention may leads to lower treatment completers (low certainty).
1 finding from 1 review
Severity of PTSD symptoms · Individuals with post‐traumatic stress disorder and comorbid substance use disorder
1 finding from 1 review
Drug or alcohol use, or both following treatment completion ‐ Individual‐based intervention · Individuals with post‐traumatic stress disorder and comorbid substance use disorder
1 finding from 1 review
Treatment completers · Individuals with post‐traumatic stress disorder and comorbid substance use disorder
Trauma‐focused psychological intervention showed no clear difference in treatment completers compared with active psychological intervention (low certainty).
1 finding from 1 review