Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,494 questions · 1,521 findings · 132 reviews · Hepato-Biliary

No studies found 303 · 19.9%GRADE not reported 39 · 2.6%Very low 876 · 57.6%Low 216 · 14.2%Moderate 65 · 4.3%High 22 · 1.4%

Fibrin‐based haemostatic agents vs non‐fibrin‐based haemostatic agents

Postoperative bile leak Median · adults undergoing liver resection for cancer or benign disease

It is very uncertain whether fibrin‐based haemostatic agents changes postoperative bile leak Median compared with non‐fibrin‐based haemostatic agents (very low certainty).

1 finding from 1 review

Fibrin‐based haemostatic agents vs placebo or no intervention

Serious adverse events Median · adults undergoing liver resection for cancer or benign disease

It is very uncertain whether fibrin‐based haemostatic agents changes serious adverse events Median compared with no intervention or placebo (very low certainty).

1 finding from 1 review

Fibrin‐based haemostatic agents vs placebo or no intervention

Postoperative transfusion Median · adults undergoing liver resection for cancer or benign disease

It is very uncertain whether fibrin‐based haemostatic agents changes postoperative transfusion Median compared with no intervention or placebo (very low certainty).

1 finding from 1 review

Fibrin‐based haemostatic agents vs placebo or no intervention

Reoperation Median · adults undergoing liver resection for cancer or benign disease

It is very uncertain whether fibrin‐based haemostatic agents changes reoperation Median compared with no intervention or placebo (very low certainty).

1 finding from 1 review

Fibrin‐based haemostatic agents vs placebo or no intervention

Postoperative bile leak Median · adults undergoing liver resection for cancer or benign disease

It is very uncertain whether fibrin‐based haemostatic agents changes postoperative bile leak Median compared with no intervention or placebo (very low certainty).

1 finding from 1 review

Fibrin‐based haemostatic agents vs non‐fibrin‐based haemostatic agents

Perioperative mortality · adults undergoing liver resection for cancer or benign disease

It is very uncertain whether fibrin‐based haemostatic agents changes perioperative mortality Median compared with non‐fibrin‐based haemostatic agents (very low certainty).

1 finding from 1 review

Fibrin‐based haemostatic agents vs non‐fibrin‐based haemostatic agents

Serious adverse events Median · adults undergoing liver resection for cancer or benign disease

Fibrin‐based haemostatic agents showed no clear difference in serious adverse events Median compared with non‐fibrin‐based haemostatic agents (low certainty).

1 finding from 1 review

Fibrin‐based haemostatic agents vs non‐fibrin‐based haemostatic agents

Postoperative transfusion Median · adults undergoing liver resection for cancer or benign disease

It is very uncertain whether fibrin‐based haemostatic agents changes postoperative transfusion Median compared with non‐fibrin‐based haemostatic agents (very low certainty).

1 finding from 1 review

Fibrin‐based haemostatic agents vs non‐fibrin‐based haemostatic agents

Reoperation Median · adults undergoing liver resection for cancer or benign disease

It is very uncertain whether fibrin‐based haemostatic agents changes reoperation Median compared with non‐fibrin‐based haemostatic agents (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Rifaximin vs placebo or no intervention

Mortality ‐ total number · prevention and treatment of hepatic encephalopathy in people with cirrhosis

Summary of findings table ‐ Rifaximin showed no clear difference in mortality ‐ total number compared with placebo/no intervention (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Rifaximin vs non‐absorbable disaccharide

Hepatic encephalopathy · prevention and treatment of hepatic encephalopathy in people with cirrhosis

Summary of findings table ‐ Rifaximin showed no clear difference in hepatic encephalopathy ‐ total number compared with non‐absorbable disaccharide (low certainty).

1 finding from 1 review

Summary of findings table ‐ Rifaximin vs non‐absorbable disaccharide

Non‐serious adverse events ‐ total number of participants · prevention and treatment of hepatic encephalopathy in people with cirrhosis

It is very uncertain whether summary of findings table ‐ Rifaximin changes non‐serious adverse events ‐ total number of participants compared with non‐absorbable disaccharide (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Rifaximin plus non‐absorbable disaccharides vs non‐absorbable disaccharide

Mortality ‐ total number · prevention and treatment of hepatic encephalopathy in people with cirrhosis

Summary of findings table ‐ Rifaximin plus non‐absorbable… probably leads to lower mortality ‐ total number compared with non‐absorbable disaccharides alone (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Rifaximin plus non‐absorbable disaccharides vs non‐absorbable disaccharide

Serious adverse events ‐ total number of participants · prevention and treatment of hepatic encephalopathy in people with cirrhosis

It is very uncertain whether summary of findings table ‐ Rifaximin plus non‐absorbable… changes serious adverse events ‐ total number of participants compared with non‐absorbable disaccharides alone (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Rifaximin plus non‐absorbable disaccharides vs non‐absorbable disaccharide

Hepatic encephalopathy · prevention and treatment of hepatic encephalopathy in people with cirrhosis

Summary of findings table ‐ Rifaximin plus non‐absorbable… may leads to lower hepatic encephalopathy ‐ total number compared with non‐absorbable disaccharides alone (low certainty).

1 finding from 1 review

Summary of findings table ‐ Rifaximin plus non‐absorbable disaccharides vs non‐absorbable disaccharide

Non‐serious adverse events ‐ total number of participants · prevention and treatment of hepatic encephalopathy in people with cirrhosis

It is very uncertain whether summary of findings table ‐ Rifaximin plus non‐absorbable… changes non‐serious adverse events ‐ total number of participants compared with non‐absorbable disaccharides alone (very low certainty).

1 finding from 1 review