Cochrane · systematic review · CD010872
Fibrin‐based haemostatic agents for reducing blood loss in adult liver resection
Malik, AK, Amer, AO, Tingle, SJ, et al. · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
Hepato-BiliaryAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
10
current version
GRADE rated
10
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 9 · 90%Low 1 · 10%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Fibrin‐based haemostatic agents versus no intervention or placebo
Population: adults undergoing liver resection for cancer or benign disease
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Perioperative mortality Median Fibrin‐based haemostatic agents vs no intervention or placebo | RR 2.58 [0.89, 7.44] | 4 studies · 782 participants | Very low Downgraded: risk of bias, imprecision |
Serious adverse events Median Fibrin‐based haemostatic agents vs no intervention or placebo | RR 0.96 [0.88, 1.05] | 4 studies · 782 participants | Very low Downgraded: risk of bias, imprecision |
Postoperative transfusion Median Fibrin‐based haemostatic agents vs no intervention or placebo | RR 1.04 [0.77, 1.4] | 5 studies · 864 participants | Very low Downgraded: risk of bias, imprecision |
Reoperation Median Fibrin‐based haemostatic agents vs no intervention or placebo | RR 2.92 [0.58, 14.61] | 2 studies · 612 participants | Very low Downgraded: risk of bias, imprecision |
Postoperative bile leak Median Fibrin‐based haemostatic agents vs no intervention or placebo | RR 1 [0.67, 1.48] | 4 studies · 782 participants | Very low Downgraded: risk of bias, imprecision |
Fibrin‐based haemostatic agents versus non‐fibrin‐based haemostatic agents
Population: adults undergoing liver resection for cancer or benign disease
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Perioperative mortality Median Fibrin‐based haemostatic agents vs non‐fibrin‐based haemostatic agents | RR 1.03 [0.62, 1.72] | 11 studies · 1436 participants | Very low Downgraded: risk of bias, imprecision |
Serious adverse events Median Fibrin‐based haemostatic agents vs non‐fibrin‐based haemostatic agents | RR 0.99 [0.95, 1.03] | 9 studies · 1176 participants | Low Downgraded: risk of bias, imprecision |
Postoperative transfusion Median Fibrin‐based haemostatic agents vs non‐fibrin‐based haemostatic agents | RR 0.92 [0.68, 1.25] | 7 studies · 599 participants | Very low Downgraded: risk of bias, imprecision |
Reoperation Median Fibrin‐based haemostatic agents vs non‐fibrin‐based haemostatic agents | RR 0.48 [0.25, 0.9] | 3 studies · 358 participants | Very low Downgraded: risk of bias, imprecision |
Postoperative bile leak Median Fibrin‐based haemostatic agents vs non‐fibrin‐based haemostatic agents | RR 1.15 [0.6, 2.21] | 9 studies · 1115 participants | Very low Downgraded: risk of bias, imprecision |