Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

475 questions · 487 findings · 49 reviews · Breast Cancer

No studies found 44 · 9%GRADE not reported 14 · 2.9%Very low 108 · 22.2%Low 128 · 26.3%Moderate 107 · 22%High 86 · 17.7%

Capecitabine‐containing regimens vs chemotherapy regimens without capecitabine

pCR: hormone receptor‐negative · neoadjuvant treatment of ER‐positive vs ER‐negative breast cancer

Capecitabine‐containing regimens showed no clear difference in pCR: hormone receptor‐negative compared with non‐capecitabine‐containing regimens (moderate certainty).

1 finding from 1 review

Capecitabine‐containing regimens vs chemotherapy regimens without capecitabine

Disease-free survival · neoadjuvant treatment of ER‐positive vs ER‐negative breast cancer

Capecitabine‐containing regimens showed no clear difference in disease‐free survivalmedian compared with non‐capecitabine‐containing regimens (high certainty).

1 finding from 1 review

Capecitabine‐containing regimens vs chemotherapy regimens without capecitabine

Overall survivalmedian · neoadjuvant treatment of ER‐positive vs ER‐negative breast cancer

Capecitabine‐containing regimens showed no clear difference in overall survivalmedian compared with non‐capecitabine‐containing regimens (high certainty).

1 finding from 1 review

Capecitabine‐containing regimens vs chemotherapy regimens without capecitabine

Febrile neutropenia · neoadjuvant treatment of ER‐positive vs ER‐negative breast cancer

Capecitabine‐containing regimens showed no clear difference in febrile neutropenia compared with non‐capecitabine‐containing regimens (moderate certainty).

1 finding from 1 review

Capecitabine‐containing regimens vs chemotherapy regimens without capecitabine

Diarrhoea · neoadjuvant treatment of ER‐positive vs ER‐negative breast cancer

Capecitabine‐containing regimens probably leads to higher diarrhoea compared with non‐capecitabine‐containing regimens (moderate certainty).

1 finding from 1 review

Capecitabine‐containing regimens vs chemotherapy regimens without capecitabine

Hand‐foot syndrome · neoadjuvant treatment of ER‐positive vs ER‐negative breast cancer

Capecitabine‐containing regimens probably leads to higher hand‐foot syndrome compared with non‐capecitabine‐containing regimens (moderate certainty).

1 finding from 1 review

Capecitabine‐containing regimens vs non‐capecitabine‐containing regimens or no chemotherapy

Disease-free survival · patients with early breast cancer

Capecitabine‐containing regimens showed no clear difference in disease‐free survival (DFS)median compared with non‐capecitabine‐containing regimens or no chemotherapy (moderate certainty).

1 finding from 1 review

Capecitabine‐containing regimens vs non‐capecitabine‐containing regimens or no chemotherapy

DFS: hormone receptor‐positivemedian · patients with early breast cancer

Capecitabine‐containing regimens showed no clear difference in DFS: hormone receptor‐positivemedian compared with non‐capecitabine‐containing regimens or no chemotherapy (moderate certainty).

1 finding from 1 review

Capecitabine‐containing regimens vs non‐capecitabine‐containing regimens or no chemotherapy

DFS: hormone receptor‐negativemedian · patients with early breast cancer

Capecitabine‐containing regimens probably leads to lower DFS: hormone receptor‐negativemedian compared with non‐capecitabine‐containing regimens or no chemotherapy (moderate certainty).

1 finding from 1 review

Capecitabine‐containing regimens vs chemotherapy regimens without capecitabine

OS: hormone receptor‐positivemedian · people with metastatic breast cancer

Capecitabine‐containing regimens showed no clear difference in OS: hormone receptor‐positivemedian compared with chemotherapy regimens without capecitabine (high certainty).

1 finding from 1 review

Capecitabine‐containing regimens vs non‐capecitabine‐containing regimens or no chemotherapy

Overall survival: Median length of · patients with early breast cancer

Capecitabine‐containing regimens probably leads to lower overall survival (OS)median compared with non‐capecitabine‐containing regimens or no chemotherapy (moderate certainty).

1 finding from 1 review

Capecitabine‐containing regimens vs non‐capecitabine‐containing regimens or no chemotherapy

Febrile neutropenia · patients with early breast cancer

Capecitabine‐containing regimens probably leads to lower febrile neutropenia compared with non‐capecitabine‐containing regimens or no chemotherapy (moderate certainty).

1 finding from 1 review

Capecitabine‐containing regimens vs non‐capecitabine‐containing regimens or no chemotherapy

Diarrhoea · patients with early breast cancer

Capecitabine‐containing regimens probably leads to higher diarrhoea compared with non‐capecitabine‐containing regimens or no chemotherapy (moderate certainty).

1 finding from 1 review

Capecitabine‐containing regimens vs non‐capecitabine‐containing regimens or no chemotherapy

Hand‐foot syndrome · patients with early breast cancer

Capecitabine‐containing regimens probably leads to higher hand‐foot syndrome compared with non‐capecitabine‐containing regimens or no chemotherapy (moderate certainty).

1 finding from 1 review

Capecitabine‐containing regimens vs chemotherapy regimens without capecitabine

OS: hormone receptor‐negativemedian · people with metastatic breast cancer

Capecitabine‐containing regimens showed no clear difference in OS: hormone receptor‐negativemedian compared with chemotherapy regimens without capecitabine (high certainty).

1 finding from 1 review

Capecitabine‐containing regimens vs chemotherapy regimens without capecitabine

Progression‐free survival · people with metastatic breast cancer

Capecitabine‐containing regimens probably leads to lower progression‐free survival (PFS)median compared with chemotherapy regimens without capecitabine (moderate certainty).

1 finding from 1 review

Capecitabine‐containing regimens vs chemotherapy regimens without capecitabine

PFS: hormone receptor‐positivemedian · people with metastatic breast cancer

Capecitabine‐containing regimens probably leads to lower PFS: hormone receptor‐positivemedian compared with chemotherapy regimens without capecitabine (moderate certainty).

1 finding from 1 review

Capecitabine‐containing regimens vs chemotherapy regimens without capecitabine

PFS: hormone receptor‐negativemedian · people with metastatic breast cancer

Capecitabine‐containing regimens showed no clear difference in PFS: hormone receptor‐negativemedian compared with chemotherapy regimens without capecitabine (moderate certainty).

1 finding from 1 review

Capecitabine‐containing regimens vs chemotherapy regimens without capecitabine

Objective response rate · people with metastatic breast cancer

Capecitabine‐containing regimens showed no clear difference in objective response rate compared with chemotherapy regimens without capecitabine (moderate certainty).

1 finding from 1 review