Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

715 questions · 767 findings · 53 reviews · Back and Neck

No studies found 149 · 19.4%GRADE not reported 41 · 5.3%Very low 168 · 21.9%Low 226 · 29.5%Moderate 156 · 20.3%High 27 · 3.5%

Intervention not reported

Minor adverse events** ‒short‐term (> 2 weeks but ≤ 3 months) Minor adverse events provided as the proportion of patients reporting any untoward medical occurrence after an epidural injection without hospitalisations. · lumbosacral radicular pain

It is very uncertain whether the intervention changes minor adverse events** ‒short‐term (> 2 weeks but ≤ 3 months) Minor… (very low certainty).

1 finding from 1 review

Intervention not reported

Major adverse events** ‒short‐term (> 2 weeks but ≤ 3 months) Major adverse events provided as the proportion of patients reporting any untoward medical occurrence after an epidural injection with hospitalizations. · lumbosacral radicular pain
1 finding from 1 review

NSAIDs vs placebo

Proportion of participants experiencing global improvement % of dichotomized Likert scale · Patients with acute low‐back pain

NSAIDs may leads to higher proportion of participants experiencing global improvement Various… compared with placebo (low certainty).

1 finding from 1 review

NSAIDs vs placebo

Proportion of participants experiencing adverse events · Patients with acute low‐back pain

It is very uncertain whether NSAIDs changes proportion of participants experiencing adverse events compared with placebo (very low certainty).

1 finding from 1 review

Acupuncture vs usual care

Adverse events Self‐reported · patients with non‐specific chronic low back pain

Acupuncture showed no clear difference in adverse events Self‐reported compared with usual care (low certainty).

1 finding from 1 review