Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,562 questions · 1,645 findings · 107 reviews · Wounds

No studies found 651 · 39.6%GRADE not reported 84 · 5.1%Very low 554 · 33.7%Low 283 · 17.2%Moderate 64 · 3.9%High 9 · 0.5%

Protease‐modulating matrix dressing regimen vs any other dressing regimen

Proportion of participants with 1 or more adverse events at 2‐12 weeks · people with venous leg ulcers

Protease‐modulating matrix dressing regimen showed no clear difference in proportion of participants with 1 or more adverse events at 2‐12 weeks compared with any other dressing regimen (low certainty).

1 finding from 1 review

Intervention not reported

Diabetic ulcers healed at 1 year. · patients with chronic wounds

The intervention showed no clear difference in diabetic ulcers healed at 1 year. (moderate certainty).

1 finding from 1 review

Intervention not reported

Diabetic ulcers ‐ major amputations · patients with chronic wounds

The intervention showed no clear difference in diabetic ulcers ‐ major amputations (moderate certainty).

1 finding from 1 review

Honey vs silver sulfadiazine

Negative wound swab · people with burns

It is very uncertain whether honey changes negative wound swab compared with silver sulfadiazine (very low certainty).

1 finding from 1 review

Intervention not reported

Complete healing (time to healing) · patients with Venous leg ulcers

The intervention showed no clear difference in complete healing (time to healing) (low certainty).

1 finding from 1 review

Intervention not reported

Complete healing (proportion wounds healed) · patients with Venous leg ulcers

The intervention showed no clear difference in complete healing (proportion wounds healed) (low certainty).

1 finding from 1 review

Intervention not reported

Adverse events · patients with Venous leg ulcers

The intervention may leads to higher adverse events (low certainty).

1 finding from 1 review

Honey vs standard dressing

Adverse events · patients with Minor acute wounds

It is very uncertain whether honey changes adverse events compared with conventional dressings (very low certainty).

1 finding from 1 review

Intervention not reported

Infection · patients with Venous leg ulcers

The intervention showed no clear difference in infection (low certainty).

1 finding from 1 review