Findings

What do systematic reviews say?

1,923 questions · 1,956 findings · 143 reviews · Musculoskeletal

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No studies found 555 · 28.4%GRADE not reported 107 · 5.5%Very low 255 · 13%Low 555 · 28.4%Moderate 357 · 18.3%High 127 · 6.5%

Canakinumab vs triamcinolone acetonide

Global assessment of treatment success · acute gout

Canakinumab probably leads to higher participant global assessment of response to treatment: good or… compared with triamcinolone acetonide (moderate certainty).

1 finding from 1 review

Interleukin‐1 inhibitors for acute gout 2014 · Cochrane Headline outcomes only
RR 1.37 [1.16, 1.61]
3 studies · 478 participants
Moderate

Canakinumab vs triamcinolone acetonide

Withdrawals due to adverse events · acute gout

Canakinumab showed no clear difference in study withdrawals due to AE (all canakinumab doses) compared with triamcinolone acetonide (low certainty).

1 finding from 1 review

Interleukin‐1 inhibitors for acute gout 2014 · Cochrane Headline outcomes only
RR 1.07 [0.16, 7.23]
3 studies · 654 participants
Low

Canakinumab vs triamcinolone acetonide

Risk for at least one adverse event per patient · acute gout

Canakinumab probably leads to higher participants with at least 1 AE (all canakinumab doses) compared with triamcinolone acetonide (moderate certainty).

1 finding from 1 review

Interleukin‐1 inhibitors for acute gout 2014 · Cochrane Headline outcomes only
RR 1.2 [1.05, 1.39]
3 studies · 654 participants
Moderate

Rilonacept vs indomethacin

Pain ‐ change from baseline to 24 to 72 hours Assessed on numerical rating scale (0 = no pain; 10 = extreme pain) · acute gout

1 finding from 1 review

Interleukin‐1 inhibitors for acute gout 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 148 participants
Low

Rilonacept vs indomethacin

Inflammation ‐ not measured · acute gout

The review found no eligible studies for this question.

1 finding from 1 review

Interleukin‐1 inhibitors for acute gout 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Benzbromarone vs allopurinol

Acute gout attacks · people with chronic gout

Benzbromarone showed no clear difference in acute gout attacks compared with allopurinol (low certainty).

1 finding from 1 review

Uricosuric medications for chronic gout 2014 · Cochrane Headline outcomes only
RR 3.58 [0.15, 84.13]
1 study · 55 participants
Low

Benzbromarone vs probenecid

Withdrawals due to adverse events · people with chronic gout

Benzbromarone may leads to lower withdrawal due to adverse events compared with probenecid (low certainty).

1 finding from 1 review

Uricosuric medications for chronic gout 2014 · Cochrane Headline outcomes only
RR 0.15 [0.03, 0.79]
2 studies · 129 participants
Low

Benzbromarone vs probenecid

Total adverse events · people with chronic gout

Benzbromarone may leads to lower total adverse events compared with probenecid (low certainty).

1 finding from 1 review

Uricosuric medications for chronic gout 2014 · Cochrane Headline outcomes only
RR 0.43 [0.25, 0.74]
2 studies · 129 participants
Low

Benzbromarone vs probenecid

Pain reduction ‐ not measured · people with chronic gout

The review found no eligible studies for this question.

1 finding from 1 review

Uricosuric medications for chronic gout 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Benzbromarone vs probenecid

Function ‐ not measured · people with chronic gout

The review found no eligible studies for this question.

1 finding from 1 review

Uricosuric medications for chronic gout 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Benzbromarone vs probenecid

Tophus regression ‐ not measured · people with chronic gout

The review found no eligible studies for this question.

1 finding from 1 review

Uricosuric medications for chronic gout 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Probenecid vs allopurinol

Acute gout attacks · people with chronic gout

Probenecid showed no clear difference in acute gout attacks compared with allopurinol (low certainty).

1 finding from 1 review

Uricosuric medications for chronic gout 2014 · Cochrane Headline outcomes only
RR 0.96 [0.53, 1.75]
1 study · 37 participants
Low

Probenecid vs allopurinol

Serum urate normalisation ≤ 5 mg/dL (≤ 0.3 mmol/L) ‐ not measured · people with chronic gout

The review found no eligible studies for this question.

1 finding from 1 review

Uricosuric medications for chronic gout 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Probenecid vs allopurinol

Withdrawals due to adverse events ‐ not reported · people with chronic gout

The review found no eligible studies for this question.

1 finding from 1 review

Uricosuric medications for chronic gout 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Probenecid vs allopurinol

Total adverse events ‐ not reported · people with chronic gout

The review found no eligible studies for this question.

1 finding from 1 review

Uricosuric medications for chronic gout 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Probenecid vs allopurinol

Pain reduction ‐ not measured · people with chronic gout

The review found no eligible studies for this question.

1 finding from 1 review

Uricosuric medications for chronic gout 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Benzbromarone vs allopurinol

Serum urate normalisation ‐ not reported · people with chronic gout

Benzbromarone showed no clear difference in serum urate normalisation compared with allopurinol (moderate certainty).

1 finding from 1 review

Uricosuric medications for chronic gout 2014 · Cochrane Headline outcomes only
RR 1.27 [0.9, 1.79]
2 studies · 101 participants
Moderate

Probenecid vs allopurinol

Function ‐ not measured · people with chronic gout

The review found no eligible studies for this question.

1 finding from 1 review

Uricosuric medications for chronic gout 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Probenecid vs allopurinol

Tophus regression ‐ not measured · people with chronic gout

The review found no eligible studies for this question.

1 finding from 1 review

Uricosuric medications for chronic gout 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Benzbromarone vs allopurinol

Withdrawals due to adverse events · people with chronic gout

Benzbromarone showed no clear difference in withdrawal due to adverse events compared with allopurinol (low certainty).

1 finding from 1 review

Uricosuric medications for chronic gout 2014 · Cochrane Headline outcomes only
RR 1.25 [0.28, 5.62]
2 studies · 91 participants
Low