Findings

What do systematic reviews say?

1,562 questions · 1,645 findings · 107 reviews · Wounds

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No studies found 651 · 39.6%GRADE not reported 84 · 5.1%Very low 554 · 33.7%Low 283 · 17.2%Moderate 64 · 3.9%High 9 · 0.5%

Intervention not reported

Time to wound healing · patients aged 18 years or over with primary perianal abscess

1 finding from 1 review

Internal dressings for healing perianal abscess cavities 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 14 participants
Very low

Intervention not reported

Wound pain at initial dressing change Scale: VAS (high score= worse pain) · patients aged 18 years or over with primary perianal abscess

1 finding from 1 review

Internal dressings for healing perianal abscess cavities 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 57 participants
Very low

Intervention not reported

Wound pain over 2 weeks Scale: VAS (high score= worse pain) · patients aged 18 years or over with primary perianal abscess

1 finding from 1 review

Internal dressings for healing perianal abscess cavities 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 57 participants
Very low

Skin grafts and tissue replacements vs placebo or usual care

Healing rate · people with diabetes and foot ulcers

Skin grafts and tissue replacements may leads to higher incidence of complete closure of the ulcer (healing rate) compared with placebo or standard care (low certainty).

1 finding from 1 review

Skin grafting and tissue replacement for treating foot ulcers in people with diabetes 2016 · Cochrane Headline outcomes only
RR 1.55 [1.3, 1.85]
13 studies · 1472 participants
Low

Skin grafts and tissue replacements vs placebo or usual care

Time to ulcer closure ‐ not reported · people with diabetes and foot ulcers

1 finding from 1 review

Skin grafting and tissue replacement for treating foot ulcers in people with diabetes 2016 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Skin grafts and tissue replacements vs placebo or usual care

Total incidence of lower limb amputations · people with diabetes and foot ulcers

It is very uncertain whether skin grafts and tissue replacements changes total incidence of lower limb amputations compared with placebo or standard care (very low certainty).

1 finding from 1 review

Skin grafting and tissue replacement for treating foot ulcers in people with diabetes 2016 · Cochrane Headline outcomes only
RR 0.43 [0.23, 0.81]
2 studies · 522 participants
Very low

Topical antibiotics vs no topical antibiotic.

Surgical site infection · people presenting for surgery where healing of surgical wound planned to be by primary intention

Topical antibiotics probably leads to lower surgical site infection compared with no topical antibiotic. (moderate certainty).

1 finding from 1 review

Topical antibiotics for preventing surgical site infection in wounds healing by primary intention 2016 · Cochrane Headline outcomes only
RR 0.61 [0.42, 0.87]
7 studies · 5427 participants
Moderate

Topical antibiotics vs antiseptic agent

Number of wounds healed · people presenting for surgery where healing of surgical wound planned to be by primary intention

The review found no eligible studies for this question.

1 finding from 1 review

Topical antibiotics for preventing surgical site infection in wounds healing by primary intention 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical antibiotics vs no topical antibiotic.

Allergic contact dermatitis · people presenting for surgery where healing of surgical wound planned to be by primary intention

It is very uncertain whether topical antibiotics changes allergic contact dermatitis compared with no topical antibiotic. (very low certainty).

1 finding from 1 review

Topical antibiotics for preventing surgical site infection in wounds healing by primary intention 2016 · Cochrane Headline outcomes only
RR 3.94 [0.46, 34]
3 studies · 3012 participants
Very low

Topical antibiotics vs no topical antibiotic.

Adverse event: anaphylaxis · people presenting for surgery where healing of surgical wound planned to be by primary intention

The review found no eligible studies for this question.

1 finding from 1 review

Topical antibiotics for preventing surgical site infection in wounds healing by primary intention 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical antibiotics vs no topical antibiotic.

Antibiotic resistance · people presenting for surgery where healing of surgical wound planned to be by primary intention

The review found no eligible studies for this question.

1 finding from 1 review

Topical antibiotics for preventing surgical site infection in wounds healing by primary intention 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical antibiotics vs no topical antibiotic.

Number of wounds healed · people presenting for surgery where healing of surgical wound planned to be by primary intention

The review found no eligible studies for this question.

1 finding from 1 review

Topical antibiotics for preventing surgical site infection in wounds healing by primary intention 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical antibiotics vs antiseptic agent

Surgical site infection · people presenting for surgery where healing of surgical wound planned to be by primary intention

Topical antibiotics probably leads to lower surgical site infection compared with antiseptic (moderate certainty).

1 finding from 1 review

Topical antibiotics for preventing surgical site infection in wounds healing by primary intention 2016 · Cochrane Headline outcomes only
RR 0.49 [0.3, 0.8]
4 studies · 1299 participants
Moderate

Topical antibiotics vs antiseptic agent

Allergic contact dermatitis · people presenting for surgery where healing of surgical wound planned to be by primary intention

It is very uncertain whether topical antibiotics changes allergic contact dermatitis compared with antiseptic (very low certainty).

1 finding from 1 review

Topical antibiotics for preventing surgical site infection in wounds healing by primary intention 2016 · Cochrane Headline outcomes only
RR 0.97 [0.52, 1.82]
1 study · 541 participants
Very low

Topical antibiotics vs antiseptic agent

Adverse event: anaphylaxis · people presenting for surgery where healing of surgical wound planned to be by primary intention

The review found no eligible studies for this question.

1 finding from 1 review

Topical antibiotics for preventing surgical site infection in wounds healing by primary intention 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical antibiotics vs antiseptic agent

Antibiotic resistance · people presenting for surgery where healing of surgical wound planned to be by primary intention

The review found no eligible studies for this question.

1 finding from 1 review

Topical antibiotics for preventing surgical site infection in wounds healing by primary intention 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Protease‐modulating matrix dressing regimen vs any other dressing regimen

Time to complete healing · people with venous leg ulcers

Protease‐modulating matrix dressing regimen showed no clear difference in TIme to complete healing compared with any other dressing regimen (low certainty).

1 finding from 1 review

Protease‐modulating matrix treatments for healing venous leg ulcers 2016 · Cochrane Headline outcomes only
HR 1.21 [0.74, 1.97]
1 study · 100 participants
Low

Protease‐modulating matrix dressing regimen vs any other dressing regimen

Proportion of participants with healed ulcers at 6 weeks · people with venous leg ulcers

It is very uncertain whether protease‐modulating matrix dressing regimen changes proportion of participants healed ‐ short term (4‐8 weeks) compared with any other dressing regimen (very low certainty).

1 finding from 1 review

Protease‐modulating matrix treatments for healing venous leg ulcers 2016 · Cochrane Headline outcomes only
RR 0.73 [0.34, 1.58]
2 studies · 207 participants
Very low

Protease‐modulating matrix dressing regimen vs any other dressing regimen

Proportion of participants with healed ulcers at 12 weeks · people with venous leg ulcers

Protease‐modulating matrix dressing regimen showed no clear difference in proportion of participants healed ‐ medium term (12 weeks) compared with any other dressing regimen (low certainty).

1 finding from 1 review

Protease‐modulating matrix treatments for healing venous leg ulcers 2016 · Cochrane Headline outcomes only
RR 1.28 [0.95, 1.71]
4 studies · 192 participants
Low

Protease‐modulating matrix dressing regimen vs any other dressing regimen

Proportion of participants healed ‐ long term (over 24 weeks) · people with venous leg ulcers

Protease‐modulating matrix dressing regimen showed no clear difference in proportion of participants healed ‐ long term (over 24 weeks) compared with any other dressing regimen (low certainty).

1 finding from 1 review

Protease‐modulating matrix treatments for healing venous leg ulcers 2016 · Cochrane Headline outcomes only
RR 1.06 [0.8, 1.41]
1 study · 100 participants
Low