Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,293 questions · 2,395 findings · 172 reviews · Gut

No studies found 420 · 17.5%GRADE not reported 60 · 2.5%Very low 821 · 34.3%Low 602 · 25.1%Moderate 397 · 16.6%High 95 · 4%

H2 receptor antagonists vs placebo or no prophylaxis

Clinically important upper GI bleeding · people admitted to intensive care units

H2 receptor antagonists probably leads to lower clinically important upper GI bleeding compared with placebo or no prophylaxis (moderate certainty).

1 finding from 1 review

Prokinetic vs placebo

Not symptom‐free or no symptom improvement · patients with functional dyspepsia

It is very uncertain whether prokinetic changes not symptom‐free or no symptom improvement compared with placebo (very low certainty).

1 finding from 1 review

Prokinetic vs placebo

Adverse events · patients with functional dyspepsia

It is very uncertain whether prokinetic changes adverse events compared with placebo (very low certainty).

1 finding from 1 review

Other prokinetics vs domperidone

Not symptom‐free or no symptom improvement · patients with functional dyspepsia

It is very uncertain whether other prokinetics changes not symptom‐free or no symptoms improvement (itopride 50 three times… compared with domperidone 10mg three times a day (very low certainty).

1 finding from 1 review

Other prokinetics vs domperidone

Adverse events · patients with functional dyspepsia

It is very uncertain whether other prokinetics changes adverse events compared with domperidone 10mg three times a day (very low certainty).

1 finding from 1 review