Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,119 questions · 2,206 findings · 117 reviews · Common Mental Disorders

No studies found 387 · 17.5%GRADE not reported 111 · 5%Very low 635 · 28.8%Low 568 · 25.7%Moderate 449 · 20.4%High 56 · 2.5%

Comparison 13: SSRIs vs placebo

Global Impressions scale change item (CGI‐I or similar): no. of responders (acute phase) · adults with SAnD

It is very uncertain whether comparison 13: SSRIs changes global Impressions scale change item (CGI‐I or similar): no. of… compared with placebo (very low certainty).

1 finding from 1 review

Comparison 13: SSRIs vs placebo

Clinical Global Impressions scale change item (CGI‐I): no. of responders (long term) Post‐treatment: 1‐4 months · adults with SAnD

Comparison 13: SSRIs may leads to higher clinical Global Impressions scale change item (CGI‐I): no. of… compared with placebo (low certainty).

1 finding from 1 review

Comparison 13: SSRIs vs placebo

Dropouts due to adverse events · adults with SAnD

It is very uncertain whether comparison 13: SSRIs changes dropouts due to adverse events (long term) Post‐treatment: 1‐4 months compared with placebo (very low certainty).

1 finding from 1 review

Comparison 14: GW876008 vs placebo

Global Impressions scale change item (CGI‐I or similar): no. of responders (acute phase) · adults with SAnD

Comparison 14: GW876008 showed no clear difference in global Impressions scale change item (CGI‐I or similar): no. of… compared with placebo (moderate certainty).

1 finding from 1 review

Comparison 15: NK1 receptor antagonist GR205171 vs placebo

Global Impressions scale change item (CGI‐I or similar): no. of responders (acute phase) · adults with SAnD

It is very uncertain whether comparison 15: NK1 receptor antagonist GR205171 changes global Impressions scale change item (CGI‐I or similar): no. of… compared with placebo (very low certainty).

1 finding from 1 review

Levetiracetam vs placebo

Global Impressions scale change item (CGI‐I or similar): no. of responders (acute phase) · adults with SAnD

Comparison 3: anticonvulsant levetiracetam showed no clear difference in global Impressions scale change item (CGI‐I or similar): no. of… compared with placebo (moderate certainty).

1 finding from 1 review