Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,252 questions · 2,353 findings · 210 reviews · Neonatal

No studies found 432 · 18.4%GRADE not reported 99 · 4.2%Very low 609 · 25.9%Low 737 · 31.3%Moderate 385 · 16.4%High 91 · 3.9%

Non‐invasive ventilation vs supplemental oxygen or no treatment

Need for mechanical ventilation · patients with the management of transient tachypnea of the newborn

It is very uncertain whether non‐invasive respiratory support changes need for mechanical ventilation compared with supplemental oxygen or no treatment (very low certainty).

1 finding from 1 review

Continuous positive airway pressure (CPAP) vs nasal ventilation (NIPPV or NHFV)

Duration of tachypnea, defined as hours with respiratory rate greater than 60 breaths per minute · patients with the management of transient tachypnea of the newborn
2 findings from 1 review

Non‐invasive ventilation vs supplemental oxygen or no treatment

All‐cause mortality · patients with the management of transient tachypnea of the newborn

It is very uncertain whether non‐invasive respiratory support changes all‐cause mortality compared with supplemental oxygen or no treatment (very low certainty).

1 finding from 1 review

Continuous positive airway pressure (CPAP) vs nasal ventilation (NIPPV or NHFV)

Need for mechanical ventilation · patients with the management of transient tachypnea of the newborn

It is very uncertain whether CPAP changes need for mechanical ventilation ‒NIPPV versus CPAP compared with nasal ventilation (NIPPV or NHFV) (very low certainty).

2 findings from 1 review

Continuous positive airway pressure (CPAP) vs nasal ventilation (NIPPV or NHFV)

Pneumothorax · patients with the management of transient tachypnea of the newborn

It is very uncertain whether CPAP changes pneumothorax ‒NIPPV versus CPAP compared with nasal ventilation (NIPPV or NHFV) (very low certainty).

2 findings from 1 review

Very early treatment vs expectant management

Severe intraventricular hemorrhage in infants who received neuroimaging · preterm infants

Very early treatment showed no clear difference in severe Intraventricular hemorrhage (grades III and IV) compared with expectant management (moderate certainty).

1 finding from 1 review

Very early treatment vs expectant management

Neurodevelopmental outcomes (moderate/severe cognitive delay at 18 to 24 months) · preterm infants

Very early treatment showed no clear difference in neurodevelopmental outcomes (moderate/severe cognitive delay at 18… compared with expectant management (low certainty).

1 finding from 1 review

Very early treatment vs expectant management

Neurodevelopmental outcomes (moderate/severe motor delay at 18 to 24 months) · preterm infants

Very early treatment showed no clear difference in neurodevelopmental outcomes (moderate/severe motor delay at 18 to 24… compared with expectant management (low certainty).

1 finding from 1 review

Very early treatment vs expectant management

Neurodevelopmental outcomes (moderate/severe language delay at 18 to 24 months) · preterm infants

Very early treatment showed no clear difference in neurodevelopmental outcomes (moderate/severe language delay at 18 to… compared with expectant management (low certainty).

1 finding from 1 review

Early treatment vs expectant management

Proportion of infants requiring surgical PDA ligation or transcatheter occlusion · preterm infants

It is very uncertain whether early treatment changes proportion of infants requiring surgical PDA ligation or… compared with expectant management (very low certainty).

1 finding from 1 review

Early treatment vs expectant management

Proportion of infants receiving any pharmacotherapy for a hemodynamically significant PDA · preterm infants

Early treatment may leads to higher proportion of infants receiving any pharmacotherapy for a… compared with expectant management (low certainty).

1 finding from 1 review

Early treatment vs expectant management

Severe intraventricular hemorrhage in infants who received neuroimaging · preterm infants

Early treatment showed no clear difference in severe Intraventricular hemorrhage (grades III and IV) compared with expectant management (low certainty).

1 finding from 1 review