Findings

What do systematic reviews say?

1,923 questions · 1,956 findings · 143 reviews · Musculoskeletal

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No studies found 555 · 28.4%GRADE not reported 107 · 5.5%Very low 255 · 13%Low 555 · 28.4%Moderate 357 · 18.3%High 127 · 6.5%

Chinese herbal medicines vs Western medicine

Lumbar spine bone mineral density (BMD) · patients with osteoporosis

2 findings from 1 review

Chinese herbal medicines for treating osteoporosis 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 100 participants
Low
Chinese herbal medicines for treating osteoporosis 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 71 participants
Low

Chinese herbal medicines vs placebo

Quality of life · patients with osteoporosis

1 finding from 1 review

Chinese herbal medicines for treating osteoporosis 2014 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Chinese herbal medicines vs Western medicine

Femoral neck bone mineral density (FN-BMD) · patients with osteoporosis

1 finding from 1 review

Chinese herbal medicines for treating osteoporosis 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 71 participants
Low

Chinese herbal medicines plus western medicine vs Western medicine

New fractures · patients with osteoporosis

It is very uncertain whether chinese herbal medicines plus western medicine changes new fractures (Yigu capsule plus calcium versus placebo plus calcium) compared with western medicine (very low certainty).

4 findings from 1 review

Chinese herbal medicines for treating osteoporosis 2014 · Cochrane Headline outcomes only
RR 0.06 [0, 1]
1 study · 140 participants
Very low
Chinese herbal medicines for treating osteoporosis 2014 · Cochrane Headline outcomes only
RR 0.33 [0.01, 8.02]
1 study · 120 participants
Very low
Chinese herbal medicines for treating osteoporosis 2014 · Cochrane Headline outcomes only
RR 0.44 [0.13, 1.43]
1 study · 155 participants
Very low

Show 1 more finding

Chinese herbal medicines for treating osteoporosis 2014 · Cochrane Headline outcomes only
RR 0.22 [0.01, 5.34]
1 study · 75 participants
Very low

Chinese herbal medicines plus western medicine vs Western medicine

Quality of life (Bushenhuoxue therapy plus calcium carbonate tablets and alfacalcidol versus calcium carbonate tablets and alfacalcidol) · patients with osteoporosis

1 finding from 1 review

Chinese herbal medicines for treating osteoporosis 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 80 participants
Low

Chinese herbal medicines plus western medicine vs Western medicine

Death · patients with osteoporosis

1 finding from 1 review

Chinese herbal medicines for treating osteoporosis 2014 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Chinese herbal medicines plus western medicine vs Western medicine

Serious adverse events · patients with osteoporosis

1 finding from 1 review

Chinese herbal medicines for treating osteoporosis 2014 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Chinese herbal medicines vs placebo

Death · patients with osteoporosis

1 finding from 1 review

Chinese herbal medicines for treating osteoporosis 2014 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Chinese herbal medicines vs placebo

Serious adverse events · patients with osteoporosis

1 finding from 1 review

Chinese herbal medicines for treating osteoporosis 2014 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Chinese herbal medicines vs placebo

Lumbar spine bone mineral density (BMD) · patients with osteoporosis

1 finding from 1 review

Chinese herbal medicines for treating osteoporosis 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 140 participants
Low

Chinese herbal medicines vs placebo

BMD of ulna (Bushen Yigu soft extract versus placebo) · patients with osteoporosis

1 finding from 1 review

Chinese herbal medicines for treating osteoporosis 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 59 participants
Low

Chinese herbal medicines vs placebo

BMD of radius (Bushen Yigu soft extract versus placebo) · patients with osteoporosis

1 finding from 1 review

Chinese herbal medicines for treating osteoporosis 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 59 participants
Low

Chinese herbal medicines vs no intervention

New fractures · patients with osteoporosis

1 finding from 1 review

Chinese herbal medicines for treating osteoporosis 2014 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Chinese herbal medicines vs no intervention

Quality of life · patients with osteoporosis

1 finding from 1 review

Chinese herbal medicines for treating osteoporosis 2014 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Allopurinol vs placebo

Acute gout attacks · people with chronic gout

Allopurinol showed no clear difference in acute gout attacks compared with placebo (moderate certainty).

1 finding from 1 review

Allopurinol for chronic gout 2014 · Cochrane Headline outcomes only
RR 0.64 [0.12, 3.52]
1 study · 51 participants
Moderate

Allopurinol 100‐300 mg daily vs febuxostat 80 mg daily

Pain reduction ‐ not measured · people with chronic gout

The review found no eligible studies for this question.

1 finding from 1 review

Allopurinol for chronic gout 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Allopurinol 100‐300 mg daily vs febuxostat 80 mg daily

Function ‐ not measured · people with chronic gout

The review found no eligible studies for this question.

1 finding from 1 review

Allopurinol for chronic gout 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Allopurinol 100‐300 mg daily vs febuxostat 80 mg daily

Tophus regression · people with chronic gout

The review found no eligible studies for this question.

1 finding from 1 review

Allopurinol for chronic gout 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Allopurinol 100‐300 mg daily vs febuxostat 80 mg daily

Withdrawals due to adverse events · people with chronic gout

Allopurinol 100‐300 mg daily showed no clear difference in withdrawal due to adverse effects compared with febuxostat 80 mg daily (moderate certainty).

1 finding from 1 review

Allopurinol for chronic gout 2014 · Cochrane Headline outcomes only
RR 0.89 [0.62, 1.26]
3 studies · 2555 participants
Moderate

Allopurinol 100‐300 mg daily vs febuxostat 80 mg daily

Serious adverse effects · people with chronic gout

Allopurinol 100‐300 mg daily showed no clear difference in serious adverse effects compared with febuxostat 80 mg daily (moderate certainty).

1 finding from 1 review

Allopurinol for chronic gout 2014 · Cochrane Headline outcomes only
RR 1.13 [0.71, 1.82]
3 studies · 2556 participants
Moderate