Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,234 questions · 2,325 findings · 216 reviews · Airways

No studies found 249 · 10.7%GRADE not reported 107 · 4.6%Very low 276 · 11.9%Low 751 · 32.3%Moderate 718 · 30.9%High 224 · 9.6%

MgSO4 + SABA vs SABA

Admission to hospital at initial presentation · adults and children with acute exacerbation of asthma

MgSO4 + SABA showed no clear difference in admission to hospital at initial presentation compared with SABA (low certainty).

1 finding from 1 review

MgSO4 vs SABA

Admission to hospital at initial presentation · adults and children with acute exacerbation of asthma

It is very uncertain whether mgSO4 changes admission to hospital at initial presentation compared with SABA (very low certainty).

1 finding from 1 review

Non‐invasive ventilation vs usual care

All‐cause mortality · Patients admitted to hospital with acute hypercapnic respiratory failure due to an exacerbation of chronic obstructive pulmonary disease…

Non‐invasive ventilation probably leads to lower mortality compared with usual medical care (moderate certainty).

1 finding from 1 review

Non‐invasive ventilation vs usual care

Need for intubation · Patients admitted to hospital with acute hypercapnic respiratory failure due to an exacerbation of chronic obstructive pulmonary disease…

Non‐invasive ventilation probably leads to lower need for endotracheal intubation compared with usual medical care (moderate certainty).

1 finding from 1 review