Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,293 questions · 2,395 findings · 172 reviews · Gut

No studies found 420 · 17.5%GRADE not reported 60 · 2.5%Very low 821 · 34.3%Low 602 · 25.1%Moderate 397 · 16.6%High 95 · 4%

Two infusions of natalizumab (300 mg or 3 mg/kg) vs placebo

Failure to induce clinical response (Panaccione 2010) CDAI ‐ (≥100 point reduction) · Patients with active Crohn's disease

Two infusions of natalizumab (300 mg or 3 mg/kg) showed no clear difference in failure to induce clinical response at 6 weeks compared with placebo (low certainty).

1 finding from 1 review

Two infusions of natalizumab (6 mg/kg) vs placebo

Failure to induce remission at 6 weeks · Patients with active Crohn's disease

Two infusions of natalizumab (6 mg/kg) showed no clear difference in failure to induce remission at 6 weeks compared with placebo (moderate certainty).

2 findings from 1 review

Two infusions of natalizumab (6 mg/kg) vs placebo

Failure to induce clinical response (Panaccione 2010) CDAI ‐ (≥100 point reduction) · Patients with active Crohn's disease

Two infusions of natalizumab (6 mg/kg) showed no clear difference in failure to induce clinical response at 6 weeks compared with placebo (moderate certainty).

2 findings from 1 review