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Evidence found and GRADE certainty

4,317 questions · 75,239 findings · 5,342 reviews

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No studies found 15,213 · 20.2%GRADE not reported 10,323 · 13.7%Very low 17,528 · 23.3%Low 17,951 · 23.9%Moderate 11,190 · 14.9%High 3,034 · 4%

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Methotrexate vs placebo

Global well‐being: rated by participants · children and young people with JIA

Methotrexate showed no clear difference in participant global assessment of well‐being(up to 6 months) compared with placebo (low certainty).

1 finding from 1 review

Methotrexate vs placebo

Serious adverse events(up to 6 months) · children and young people with JIA

Methotrexate showed no clear difference in serious adverse events(up to 6 months) compared with placebo (low certainty).

1 finding from 1 review

Methotrexate vs placebo

Withdrawals due to adverse events · children and young people with JIA

Methotrexate showed no clear difference in withdrawals due to adverse events (up to 6 months) compared with placebo (low certainty).

1 finding from 1 review

Summary of findings table ‐ Energy, protein and micronutrients vs standard diet

Incidence of pressure ulcers · inpatients who are mildly or seriously malnourished or at risk of being malnourished, elderly patients at risk of developing pressure ulcers

Summary of findings table ‐ Energy, protein and micronutrients showed no clear difference in incidence of pressure ulcers compared with standard diet (low certainty).

1 finding from 1 review

Summary of findings table ‐ Protein vs standard diet

Gastrointestinal adverse events · patients (> 65 years) following hip fracture; patients with a recent stroke

It is very uncertain whether summary of findings table ‐ Protein changes side effects: at least one adverse gastrointestinal event compared with standard diet (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Energy, protein and micronutrients vs standard diet

The proportion of pressure ulcers healed · long‐term care patients; inpatients without dehydration with energy intake by tube feeding; patients with pressure ulcers

Summary of findings table ‐ Energy, protein and micronutrients may leads to higher pressure ulcers healed compared with standard diet (low certainty).

1 finding from 1 review

Summary of findings table ‐ Energy, protein and micronutrients vs standard diet

Time to complete healing of pressure ulcers ‐ not reported · long‐term care patients; inpatients without dehydration with energy intake by tube feeding; patients with pressure ulcers

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings table ‐ Energy, protein and micronutrients vs standard diet

Change in area/depth/volume of pressure ulcers ‐ not reported · long‐term care patients; inpatients without dehydration with energy intake by tube feeding; patients with pressure ulcers

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings table ‐ Energy, protein and micronutrients vs standard diet

Acceptability of nutritional supplements ‐ not reported · long‐term care patients; inpatients without dehydration with energy intake by tube feeding; patients with pressure ulcers

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings table ‐ Energy, protein and micronutrients vs standard diet

Gastrointestinal adverse events · long‐term care patients; inpatients without dehydration with energy intake by tube feeding; patients with pressure ulcers

It is very uncertain whether summary of findings table ‐ Energy, protein and micronutrients changes side effects: at least one adverse gastrointestinal event compared with standard diet (very low certainty).

1 finding from 1 review