Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,252 questions · 2,353 findings · 210 reviews · Neonatal

No studies found 432 · 18.4%GRADE not reported 99 · 4.2%Very low 609 · 25.9%Low 737 · 31.3%Moderate 385 · 16.4%High 91 · 3.9%

Exposure vs no exposure to the smell and taste of milk with tube feeds

Late infection during hospitalisation (bacterial or fungal infection confirmed by presence of blood or CSF infection, with initiation of symptoms > 48 hours after birth) · preterm infants

Exposure showed no clear difference in late infection during hospitalisation (bacterial or fungal infection… compared with no exposure to the smell and taste of milk with tube feeds (moderate certainty).

1 finding from 1 review

Familiar odour (breast milk smell) vs usual care

Pain (PIPP) · neonates with mechanical ventilation

Familiar odour (breast milk smell) showed no clear difference in PIPP during endotracheal suctioning Range of scale 0 to 21. Lower… compared with standard care (low certainty).

1 finding from 1 review

Facilitated tucking / four‐handed care / gentle human touch vs usual care

Pain (PIPP) · neonates with mechanical ventilation

Facilitated tucking / four‐handed care / gentle human touch showed no clear difference in PIPP during endotracheal suctioning Range of scale 0 to 21. Lower… compared with standard care (moderate certainty).

1 finding from 1 review

Facilitated tucking / four‐handed care / gentle human touch vs usual care

Heart rate · neonates with mechanical ventilation

Facilitated tucking / four‐handed care / gentle human touch showed no clear difference in heart rate compared with standard care (low certainty).

1 finding from 1 review

Facilitated tucking / four‐handed care / gentle human touch vs usual care

SaO 2 during endotracheal suctioning · neonates with mechanical ventilation

Facilitated tucking / four‐handed care / gentle human touch showed no clear difference in saO 2 during endotracheal suctioning compared with standard care (low certainty).

1 finding from 1 review