Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

161 questions · 165 findings · 15 reviews · Childhood Cancer

No studies found 50 · 30.3%GRADE not reported 12 · 7.3%Very low 13 · 7.9%Low 69 · 41.8%Moderate 21 · 12.7%High 0 · 0%

Retinoic acid post‐consolidation therapy vs no further treatment

Overall survival (reported as mortality) · high‐risk neuroblastoma patients treated with autologous HSCT

Retinoic acid postconsolidation therapy showed no clear difference in overall survival (reported as mortality) compared with no further treatment (low certainty).

1 finding from 1 review

Retinoic acid post‐consolidation therapy vs no further treatment

Event‐free survival · high‐risk neuroblastoma patients treated with autologous HSCT

Retinoic acid postconsolidation therapy showed no clear difference in event‐free survival (reported as relapse, disease progression, death… compared with no further treatment (low certainty).

1 finding from 1 review

Early discharge vs non‐early discharge

Treatment failure; rehospitalization or adjustment of antimicrobial treatment (or both) in number of episodes · children with cancer

Early discharge showed no clear difference in treatment failure; rehospitalization or adjustment of antimicrobial… compared with non‐early discharge (low certainty).

1 finding from 1 review