Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

475 questions · 487 findings · 49 reviews · Breast Cancer

No studies found 44 · 9%GRADE not reported 14 · 2.9%Very low 108 · 22.2%Low 128 · 26.3%Moderate 107 · 22%High 86 · 17.7%

Intervention not reported

Service provision (patient perspective) · women with advanced breast cancer

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Cancer‐specific quality of life [assessed using a variety of scales, · women with primary breast cancer

The intervention may leads to lower cancer‐specific quality of life [assessed using a variety of scales, (low certainty).

1 finding from 1 review

Intervention not reported

Anxiety and depression [assessed using a variety of scales, · women with primary breast cancer

The intervention may leads to lower anxiety and depression [assessed using a variety of scales, (low certainty).

1 finding from 1 review

Intervention not reported

General health‐related quality of life [GHQ‐28, IES, · women with primary breast cancer

It is very uncertain whether the intervention changes general health‐related quality of life [GHQ‐28, IES, (very low certainty).

1 finding from 1 review

Intervention not reported

Cancer‐specific quality of life [EORTC QLQ‐C30, EORTC‐BR23, · women with primary breast cancer

It is very uncertain whether the intervention changes cancer‐specific quality of life [EORTC QLQ‐C30, EORTC‐BR23, (very low certainty).

1 finding from 1 review

Intervention not reported

Anxiety and Depression [HADS, STAI, · women with primary breast cancer

It is very uncertain whether the intervention changes anxiety and Depression [HADS, STAI, (very low certainty).

1 finding from 1 review

Capecitabine‐containing regimens vs chemotherapy regimens without capecitabine

Overall survival: Median length of · people with metastatic breast cancer

Capecitabine‐containing regimens showed no clear difference in overall survival (OS)median compared with chemotherapy regimens without capecitabine (high certainty).

1 finding from 1 review

Capecitabine‐containing regimens vs chemotherapy regimens without capecitabine

pCR: hormone receptor‐positive · neoadjuvant treatment of ER‐positive vs ER‐negative breast cancer

Capecitabine‐containing regimens showed no clear difference in pCR: hormone receptor‐positive compared with non‐capecitabine‐containing regimens (moderate certainty).

1 finding from 1 review