Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,501 questions · 1,558 findings · 115 reviews · Vascular

No studies found 346 · 22.2%GRADE not reported 90 · 5.8%Very low 281 · 18%Low 477 · 30.6%Moderate 313 · 20.1%High 51 · 3.3%

IM injection vs IA injection

Improvement in lower limb perfusion: ABI · people with critical limb ischaemia

It is very uncertain whether IM injection changes improvement in lower limb perfusion: number of participants with… compared with IA injection (very low certainty).

1 finding from 1 review

IM injection vs IA injection

Improvement in lower limb perfusion: number of participants with improved TcO₂ reading · people with critical limb ischaemia

It is very uncertain whether IM injection changes improvement in lower limb perfusion: number of participants with… compared with IA injection (very low certainty).

1 finding from 1 review

Gene therapy vs no gene therapy control

Above‐ankle amputation · peripheral arterial disease

Gene therapy showed no clear difference in amputation (above‐ankle amputation of the index limb) compared with no gene therapy control (moderate certainty).

1 finding from 1 review