Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,501 questions · 1,558 findings · 115 reviews · Vascular

No studies found 346 · 22.2%GRADE not reported 90 · 5.8%Very low 281 · 18%Low 477 · 30.6%Moderate 313 · 20.1%High 51 · 3.3%

PTA vs stent

Technical success · people with infrapopliteal arterial lesions in chronic limb‐threatening ischaemia

PTA probably leads to higher technical success ITT No. of limbs: 476 (5 RCTs) compared with stent (moderate certainty).

2 findings from 1 review

PTA vs stent

Procedural complications · people with infrapopliteal arterial lesions in chronic limb‐threatening ischaemia

PTA showed no clear difference in procedural complications ITT No. of participants: 360 (5 RCTs) compared with stent (moderate certainty).

2 findings from 1 review

PTA vs stent

Primary patency ( · people with infrapopliteal arterial lesions in chronic limb‐threatening ischaemia

PTA showed no clear difference in primary patency < 6 months ITT No. of lesions: 456 (3 RCTs) compared with stent (moderate certainty).

2 findings from 1 review

Prostanoids vs lumbar sympathectomy

Complete ulcer healing without rest pain or major amputation (per protocol) Clinical assessment · people with critical limb ischaemia due to non‐reconstructable peripheral arterial disease

Prostanoids may leads to higher complete ulcer healing without rest pain or major amputation (per… compared with lumbar sympathectomy (low certainty).

1 finding from 1 review

Prostanoids vs lumbar sympathectomy

Quality of life at post‐treatment Indexed by self‐report measures of quality of life or functional disability · people with critical limb ischaemia due to non‐reconstructable peripheral arterial disease

The review found no eligible studies for this question.

1 finding from 1 review

Endovascular revascularisation vs conservative therapy

Pain‐free walking distance · intermittent claudication
2 findings from 1 review

Endovascular revascularisation plus conservative therapy vs conservative therapy

Maximum walking distance · intermittent claudication
2 findings from 1 review

Endovascular revascularisation plus conservative therapy vs conservative therapy

Pain‐free walking distance · intermittent claudication
2 findings from 1 review