Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,923 questions · 1,956 findings · 143 reviews · Musculoskeletal

No studies found 555 · 28.4%GRADE not reported 107 · 5.5%Very low 255 · 13%Low 555 · 28.4%Moderate 357 · 18.3%High 127 · 6.5%

Intervention not reported

Number of patients with at least 30% pain reduction · Patients with fibromyalgia

It is very uncertain whether the intervention changes number of patients with at least 30% pain reduction (very low certainty).

1 finding from 1 review

Intervention not reported

Number of patients with a clinically important global improvement · Patients with fibromyalgia

It is very uncertain whether the intervention changes number of patients with a clinically important global improvement (very low certainty).

1 finding from 1 review

Intervention not reported

Discontinuation due to adverse events · Patients with fibromyalgia

It is very uncertain whether the intervention changes discontinuation due to adverse events (very low certainty).

1 finding from 1 review

Intervention not reported

Serious adverse events · Patients with fibromyalgia

It is very uncertain whether the intervention changes serious adverse events (very low certainty).

1 finding from 1 review

Intervention not reported

ACR 50 American College of Rheumatology improvement criteria · patients with rheumatoid arthritis

The intervention probably leads to higher ACR 50 American College of Rheumatology improvement criteria (moderate certainty).

1 finding from 1 review

Intervention not reported

Remission3 · patients with rheumatoid arthritis
1 finding from 1 review

Intervention not reported

Functional Status Health Assessment Questionnaire Disability Index . Scale from: 0 to 3 · patients with rheumatoid arthritis
1 finding from 1 review

Intervention not reported

Health‐Related Quality of Life at least 20% improvement · patients with rheumatoid arthritis

The intervention showed no clear difference in health‐Related Quality of Life at least 20% improvement (moderate certainty).

1 finding from 1 review

Intervention not reported

Radiographic Progression Increase in erosion scores of > 3 units · patients with rheumatoid arthritis

The intervention probably leads to lower radiographic Progression Increase in erosion scores of > 3 units (moderate certainty).

1 finding from 1 review

Intervention not reported

Discontinuations due to adverse events · patients with rheumatoid arthritis

The intervention leads to higher discontinuations due to adverse events (high certainty).

1 finding from 1 review

Intervention not reported

Serious Adverse Events · patients with rheumatoid arthritis

The intervention showed no clear difference in serious Adverse Events (moderate certainty).

1 finding from 1 review

Intervention not reported

Pain Global pain 0‐3 (higher scores mean worse) · patients with treating osteoarthritis
1 finding from 1 review

Intervention not reported

Adverse events Adverse event episodes (n) reported · patients with treating osteoarthritis

The intervention probably leads to lower adverse events Adverse event episodes (n) reported (moderate certainty).

1 finding from 1 review