Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,497 questions · 1,590 findings · 129 reviews · Gynaecological, Neuro-oncology and Orphan Cancer

No studies found 281 · 17.7%GRADE not reported 74 · 4.7%Very low 410 · 25.8%Low 420 · 26.4%Moderate 280 · 17.6%High 125 · 7.9%

Risk‐reducing salpingo‐oophorectomy (RRSO) vs no RRSO

Incidence of fractures
4 findings from 1 review
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Risk‐reducing salpingo‐oophorectomy (RRSO) vs no RRSO

Severe adverse events
4 findings from 1 review
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Risk‐reducing salpingo‐oophorectomy (RRSO) vs no RRSO

Breast cancer mortality: ≤ 50 years

It is very uncertain whether risk‐reducing salpingo‐oophorectomy (RRSO) changes breast cancer mortality: ≤ 50 years compared with no RRSO (very low certainty).

2 findings from 1 review

Risk‐reducing salpingo‐oophorectomy (RRSO) vs no RRSO

Breast cancer mortality: > 50 years

It is very uncertain whether risk‐reducing salpingo‐oophorectomy (RRSO) changes breast cancer mortality: > 50 years compared with no RRSO (very low certainty).

2 findings from 1 review

Risk‐reducing salpingo‐oophorectomy (RRSO) vs no RRSO according to BRCA mutation status

Overall survival: BRCA1 only

It is very uncertain whether risk‐reducing salpingo‐oophorectomy (RRSO) changes overall survival: BRCA1 only compared with no RRSO according to BRCA mutation status (very low certainty).

1 finding from 1 review

Risk‐reducing salpingo‐oophorectomy (RRSO) vs no RRSO according to BRCA mutation status

Overall survival: BRCA2 only

It is very uncertain whether risk‐reducing salpingo‐oophorectomy (RRSO) changes overall survival: BRCA2 only compared with no RRSO according to BRCA mutation status (very low certainty).

1 finding from 1 review