Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,495 questions · 1,554 findings · 140 reviews · Heart

No studies found 272 · 17.5%GRADE not reported 44 · 2.8%Very low 329 · 21.2%Low 464 · 29.9%Moderate 319 · 20.5%High 126 · 8.1%

Intervention not reported

New/intensified lipid‐lowering medication · adults without prevalent cardiovascular disease (primary cardiovascular disease prevention)

The intervention may leads to higher new/intensified lipid‐lowering medication (low certainty).

1 finding from 1 review

Intervention not reported

New/intensified antihypertensive medication · adults without prevalent cardiovascular disease (primary cardiovascular disease prevention)

The intervention may leads to higher new/intensified antihypertensive medication (low certainty).

1 finding from 1 review

Intervention not reported

Total mortality at the end of the · patients with coronary heart disease

The intervention showed no clear difference in total mortality at the end of the (moderate certainty).

1 finding from 1 review

Intervention not reported

Fatal and/or non‐fatal MI at the end of the · patients with coronary heart disease

It is very uncertain whether the intervention changes fatal and/or non‐fatal MI at the end of the (very low certainty).

1 finding from 1 review

Intervention not reported

Other fatal and/or non‐fatal cardiovascular events · patients with coronary heart disease

The intervention may leads to lower other fatal and/or non‐fatal cardiovascular events (low certainty).

1 finding from 1 review

Intervention not reported

Total revascularisations (including CABG and PCI) · patients with coronary heart disease

It is very uncertain whether the intervention changes total revascularisations (including CABG and PCI) (very low certainty).

1 finding from 1 review

Intervention not reported

Hospitalisations (cardiac‐related)at end of · patients with coronary heart disease

It is very uncertain whether the intervention changes hospitalisations (cardiac‐related)at end of (very low certainty).

1 finding from 1 review

Intervention not reported

All cause withdrawal at · patients with coronary heart disease

The intervention showed no clear difference in all cause withdrawal at (low certainty).

1 finding from 1 review

Intervention not reported

Overall mortality ( · people with or at risk of cardiovascular disease

The intervention showed no clear difference in overall mortality ( (high certainty).

1 finding from 1 review

Intervention not reported

Cardiovascular mortality ( · people with or at risk of cardiovascular disease

The intervention showed no clear difference in cardiovascular mortality ( (moderate certainty).

1 finding from 1 review

Intervention not reported

Non‐cardiovascular mortality ( · people with or at risk of cardiovascular disease

The intervention showed no clear difference in non‐cardiovascular mortality ( (high certainty).

1 finding from 1 review

Intervention not reported

Fatal or non‐fatal myocardial infarction ( · people with or at risk of cardiovascular disease

The intervention showed no clear difference in fatal or non‐fatal myocardial infarction ( (moderate certainty).

1 finding from 1 review

Intervention not reported

Fatal and non‐fatal stroke ( · people with or at risk of cardiovascular disease

The intervention showed no clear difference in fatal and non‐fatal stroke ( (low certainty).

1 finding from 1 review

Intervention not reported

Discontinuation of treatment due to side effects ( · people with or at risk of cardiovascular disease

The intervention probably leads to higher discontinuation of treatment due to side effects ( (moderate certainty).

1 finding from 1 review

Intervention not reported

All‐cause mortality Median · adults older than 18 years, with no restriction regarding presence of ASCVD; participants generally had elevated risk of ASCVD (as…

The intervention showed no clear difference in all‐cause mortality Median (low certainty).

1 finding from 1 review