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What do systematic reviews say?

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Evidence found and GRADE certainty

1,562 questions · 1,645 findings · 107 reviews · Wounds

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No studies found 651 · 39.6%GRADE not reported 84 · 5.1%Very low 554 · 33.7%Low 283 · 17.2%Moderate 64 · 3.9%High 9 · 0.5%

Intervention not reported

Ulcers completely healed · varied

The intervention showed no clear difference in ulcers completely healed (low certainty).

1 finding from 1 review

NPWT vs dressings

Proportion of wounds healed · treating foot wounds in people with diabetes mellitus

NPWT may leads to higher proportion of wounds healed compared with dressings (low certainty).

2 findings from 1 review

NPWT vs dressings

Amputation · treating foot wounds in people with diabetes mellitus

NPWT may leads to lower amputations compared with dressings (low certainty).

2 findings from 1 review

NPWT vs dressings

Number of wounds closed or covered with surgery · treating foot wounds in people with diabetes mellitus

NPWT showed no clear difference in number of wounds closed or covered with surgery compared with dressings (low certainty).

2 findings from 1 review

NPWT vs dressings

Adverse events · treating foot wounds in people with diabetes mellitus

The review found no eligible studies for this question.

2 findings from 1 review

NPWT vs dressings

Cost‐effectiveness · treating foot wounds in people with diabetes mellitus

The review found no eligible studies for this question.

2 findings from 1 review

NPWT vs dressings

Wound recurrence · treating foot wounds in people with diabetes mellitus

It is very uncertain whether NPWT changes wound recurrence compared with dressings (very low certainty).

2 findings from 1 review

Low‐pressure vs high‐pressure NPWT

Number of wounds closed or covered with surgery · treating foot wounds in people with diabetes mellitus

It is very uncertain whether low‐pressure changes number of wounds closed or covered with surgery compared with high‐pressure NPWT (very low certainty).

1 finding from 1 review

NPWT vs dressings

Ulcer healing · treating foot wounds in people with diabetes mellitus

NPWT may leads to higher time to healing compared with dressings (low certainty).

2 findings from 1 review

Training, monitoring and observation vs monitoring and observation

Proportion of participants developing a new pressure ulcer · staff caring for patients at risk of pressure ulcers

It is very uncertain whether training, monitoring and observation changes incidence of new pressure ulcers compared with monitoring and observation (very low certainty).

1 finding from 1 review