Major bleeding · people with coronary disease, ischaemic cerebrovascular disease, peripheral arterial disease or at high risk of atherothrombotic disease
clopidogrel plus aspirin probably leads to higher major bleeding compared with aspirin alone (moderate certainty).
1 finding from 1 review
Minor bleeding · people with coronary disease, ischaemic cerebrovascular disease, peripheral arterial disease or at high risk of atherothrombotic disease
clopidogrel plus aspirin probably leads to higher minor bleeding compared with aspirin alone (moderate certainty).
1 finding from 1 review
Myocardial infarction · people with or without existing cardiovascular disease, men and women
Homocysteine‐lowering interventions (Vitamin B6 (pyridoxine;… showed no clear difference in myocardial infarction compared with placebo or standard care (high certainty).
1 finding from 1 review
Stroke · patients with hypertension
Enalapril plus folic acid leads to lower stroke compared with enalapril (high certainty).
1 finding from 1 review
First unstable angina pectoris episode requiring hospitalisation · patients with hypertension
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Death from any cause · patients with hypertension
Enalapril plus folic acid showed no clear difference in death from any cause compared with enalapril (high certainty).
1 finding from 1 review
Serious adverse event (cancer) · patients with hypertension
Enalapril plus folic acid showed no clear difference in serious adverse event (cancer) compared with enalapril (moderate certainty).
1 finding from 1 review
Stroke · people with or without existing cardiovascular disease, men and women
Homocysteine‐lowering interventions (Vitamin B6 (pyridoxine;… leads to lower stroke compared with placebo or standard care (high certainty).
1 finding from 1 review
Death by any cause · people with or without existing cardiovascular disease, men and women
Homocysteine‐lowering interventions (Vitamin B6 (pyridoxine;… showed no clear difference in death by any cause compared with placebo or standard care (high certainty).
1 finding from 1 review
Adverse events · people with or without existing cardiovascular disease, men and women
Homocysteine‐lowering interventions (Vitamin B6 (pyridoxine;… showed no clear difference in adverse events compared with placebo or standard care (high certainty).
1 finding from 1 review
Myocardial infarction · people with or without existing cardiovascular disease, men and women
Homocysteine‐lowering interventions (high dose) showed no clear difference in myocardial infarction compared with homocysteine‐lowering interventions (low dose) (moderate certainty).
1 finding from 1 review
Stroke · people with or without existing cardiovascular disease, men and women
It is very uncertain whether homocysteine‐lowering interventions (high dose) changes stroke compared with homocysteine‐lowering interventions (low dose) (very low certainty).
1 finding from 1 review
Death by any cause · people with or without existing cardiovascular disease, men and women
Homocysteine‐lowering interventions (high dose) showed no clear difference in death by any cause compared with homocysteine‐lowering interventions (low dose) (moderate certainty).
1 finding from 1 review
Cancer · people with or without existing cardiovascular disease, men and women
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Myocardial infarction · patients with hypertension
Enalapril plus folic acid showed no clear difference in myocardial infarction compared with enalapril (moderate certainty).
1 finding from 1 review
Intervention not reported
CVD events · adults without prevalent cardiovascular disease (primary cardiovascular disease prevention)
The intervention showed no clear difference in CVD events (low certainty).
1 finding from 1 review
Intervention not reported
Total cholesterol (mmol/L) · adults without prevalent cardiovascular disease (primary cardiovascular disease prevention)
1 finding from 1 review
Intervention not reported
Systolic blood pressure (mmHg) · adults without prevalent cardiovascular disease (primary cardiovascular disease prevention)
1 finding from 1 review
Intervention not reported
Change in multivariable CVD risk (SD) · adults without prevalent cardiovascular disease (primary cardiovascular disease prevention)
1 finding from 1 review
Intervention not reported
Investigator‐defined adverse events · adults without prevalent cardiovascular disease (primary cardiovascular disease prevention)
The intervention showed no clear difference in investigator‐defined adverse events (low certainty).
1 finding from 1 review